Division of Vascular and Interventional Radiology, Medical University of South Carolina, Charleston, SC 29425, USA.
J Vasc Interv Radiol. 2011 Nov;22(11):1619-1624.e1. doi: 10.1016/j.jvir.2011.08.009. Epub 2011 Sep 23.
To compare an injectable hydrogel embolic device with a pushable AZUR device procedurally, angiographically, and histologically in the embolization of porcine arteries.
In 12 pigs, embolization of renal, gluteal, and hepatic or thoracic arteries was performed with either injectable hydrogel embolic devices (two arteries per pig) or an AZUR device (one artery per pig). Follow-up angiography was performed before sacrifice in five pigs at 7 days after embolization and seven pigs at 90 days after embolization. The harvested tissues were evaluated histologically. Continuous and ordinal results were compared using analysis of variance and χ(2) tests.
For the sites with embolization performed with injectable hydrogel, complete angiographic occlusion was obtained in 21 of 24 (88%) sites after treatment, 10 of 10 (100%) sites at 7 days, and 10 of 14 (72%) sites at 90 days. For the sites with embolization performed with AZUR devices, complete angiographic occlusion was obtained in 10 of 12 (83%) sites after treatment, 4 of 5 (80%) sites at 7 days, and 5 of 7 (72%) sites at 90 days. Statistically significant differences in angiographic occlusion were not observed at 7 days (P = .13) or 90 days (P = .35). The embolization time of the injectable hydrogel group (14 minutes ± 8) was significantly reduced (P = .02) compared with the AZUR group (22 minutes ± 12). Differences between the groups in arterial wall damage were not evident at either 7 days or 90 days, although greater damage was observed in both groups at 90 days. In both groups, inflammation was nonexistent to minimal at 7 days and minimal to mild at 90 days.
Embolization of porcine arteries was as effective with injectable hydrogel embolic devices as pushable AZUR devices, as evidenced by the procedural, angiographic, and histologic results.
比较可注射水凝胶栓塞装置和可推送 AZUR 装置在栓塞猪动脉中的程序性、血管造影和组织学表现。
在 12 头猪中，使用可注射水凝胶栓塞装置（每头猪两条动脉）或 AZUR 装置（每头猪一条动脉）栓塞肾动脉、臀动脉、肝动脉或胸主动脉。在栓塞后 7 天的 5 头猪和 90 天的 7 头猪处死前进行了随访血管造影。评估了收获的组织的组织学表现。使用方差分析和 χ(2)检验比较连续和有序结果。
对于使用可注射水凝胶进行栓塞的部位，治疗后 24 个部位中的 21 个（88%）完全闭塞，7 天时 10 个（100%）完全闭塞，90 天时 14 个（72%）完全闭塞。对于使用 AZUR 装置进行栓塞的部位，治疗后 12 个部位中的 10 个（83%）完全闭塞，7 天时 5 个（80%）完全闭塞，90 天时 7 个（72%）完全闭塞。7 天时（P =.13）和 90 天时（P =.35）的血管造影闭塞无统计学差异。与 AZUR 组（22 分钟±12）相比，可注射水凝胶组的栓塞时间（14 分钟±8 分钟）明显缩短（P =.02）。两组在 7 天和 90 天时的动脉壁损伤差异不明显，但两组在 90 天时的损伤都较大。两组在 7 天时均无炎症或炎症轻微，90 天时均为轻度至中度炎症。
可注射水凝胶栓塞装置与可推送 AZUR 装置栓塞猪动脉的效果相当，程序性、血管造影和组织学结果均如此。
