Metastasis and Angiogenesis Research Group, Institute of Cancer and Genetics, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
Anticancer Res. 2013 Jan;33(1):207-14.
Hepatitis A virus cellular receptor 1 (HAVcR-1) may function as part of the regulatory apparatus for tight junction in human endothelial cells, and is overexpressed in renal cell and ovarian clear cell carcinomas.
HAVcR-1 expression in colorectal cancer and matched background tissues was determined using quantitative-PCR. HAVcR-1 was overexpressed in three colorectal cancer cell lines and the effect of this overexpression was assessed by changes in cell behaviour.
HAVcR-1 expression was increased in colorectal cancer (p<0.001) and the disease-free time of patients with high levels of HAVcR-1 expression was significantly longer (p=0.045). HAVcR-1 overexpression reduced colorectal cancer cell adhesion and invasion (p<0.016).
HAVcR-1 overexpression may be a diagnostic biomarker for colorectal cancer and a prognostic marker for a longer disease-free interval after surgery for colorectal cancer. HAVcR-1 overexpression can reduce cell adhesion and invasion and could thus be involved in the metastatic cascade.
甲型肝炎病毒细胞受体 1（HAVcR-1）可能作为人内皮细胞紧密连接调节装置的一部分发挥作用，并且在肾细胞癌和卵巢透明细胞癌中过度表达。
使用定量 PCR 检测结直肠癌和匹配背景组织中的 HAVcR-1 表达。在三种结直肠癌细胞系中过表达 HAVcR-1，并通过细胞行为的变化评估这种过表达的影响。
HAVcR-1 的表达在结直肠癌中增加（p<0.001），HAVcR-1 高表达患者的无病时间明显更长（p=0.045）。HAVcR-1 过表达降低了结直肠癌细胞的黏附和侵袭（p<0.016）。
HAVcR-1 过表达可能是结直肠癌的诊断生物标志物，也是结直肠癌手术后无病间隔时间延长的预后标志物。HAVcR-1 过表达可降低细胞黏附和侵袭，因此可能参与转移级联反应。
