Seeds N W, Marks M J
Dev Neurosci. 1979;2(6):249-53. doi: 10.1159/000112488.
Several neural cell lines were examined for their ability to synthesize sulfatide and 2',3'-cyclic nucleotide phosphohydrolase, biochemical components characteristic of myelin. The mouse glioma G26 and the rat schwannoma TRM6B actively produced sulfatide, while the rat glioma C6 was inactive, supporting the probable oligodendroglial origin of the G26. In contrast, the C6 cell line had a high level of 2'-3'-cyclic nucleotide phosphohydrolase activity, while TRM6B showed 30% and the G26 75% lower activities. Thus, these two activities appear to be independently regulated.
研究了几种神经细胞系合成硫苷脂和2',3'-环核苷酸磷酸水解酶（髓鞘的生化特征成分）的能力。小鼠胶质瘤G26和大鼠雪旺细胞瘤TRM6B能活跃地产生硫苷脂，而大鼠胶质瘤C6则无此活性，这支持了G26可能起源于少突胶质细胞的观点。相反，C6细胞系具有高水平的2'-3'-环核苷酸磷酸水解酶活性，而TRM6B的活性低30%，G26的活性低75%。因此，这两种活性似乎是独立调节的。
