Murthy K K, Calnek B W
Infect Immun. 1979 Nov;26(2):547-53. doi: 10.1128/iai.26.2.547-553.1979.
Inactivated Marek's disease virus-infected chicken kidney cells and inactivated MSB-1 lymphoblastoid Marek's disease tumor cells were used to immunize chickens as virus- and tumor-associated antigens, respectively. Immune and nonimmune birds were then challenged by exposure to live virulent Marek's disease virus. Both vaccines protected significant numbers of chickens (P less than 0.05) against subsequent tumor development, although viral antigen appeared superior to tumor antigen. After challenge, the early appearance of viral antigen, infected lymphocytes, and degenerative changes in lymphoid organs was inhibited only by the viral antigen vaccine, whereas the early appearance of cells bearing tumor antigen was prevented by both vaccines. These results support the hypothesis that effective immunity in Marek's disease could be directed against either virus replication and spread or events associated with transformation and proliferation of lymphoid cells.
用灭活的马立克氏病病毒感染的鸡肾细胞和灭活的MSB - 1马立克氏病肿瘤淋巴母细胞分别作为病毒相关抗原和肿瘤相关抗原对鸡进行免疫。然后，将免疫和未免疫的鸡暴露于强毒马立克氏病病毒进行攻毒。两种疫苗都保护了大量的鸡（P小于0.05）使其免受随后的肿瘤发生，尽管病毒抗原似乎优于肿瘤抗原。攻毒后，仅病毒抗原疫苗抑制了病毒抗原、感染淋巴细胞的早期出现以及淋巴器官的退行性变化，而两种疫苗都阻止了携带肿瘤抗原细胞的早期出现。这些结果支持这样的假说，即马立克氏病的有效免疫可以针对病毒复制和传播或与淋巴细胞转化和增殖相关的事件。
