Pohlack Sebastian T, Meyer Patric, Cacciaglia Raffaele, Liebscher Claudia, Ridder Stephanie, Flor Herta
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J 5, 68159, Mannheim, Germany.
Brain Struct Funct. 2014 Jan;219(1):255-67. doi: 10.1007/s00429-012-0497-z. Epub 2012 Dec 27.
The importance of the hippocampus for declarative memory processes is firmly established. Nevertheless, the issue of a correlation between declarative memory performance and hippocampal volume in healthy subjects still remains controversial. The aim of the present study was to investigate this relationship in more detail. For this purpose, 50 healthy young male participants performed the California Verbal Learning Test. Hippocampal volume was assessed by manual segmentation of high-resolution 3D magnetic resonance images. We found a significant positive correlation between putatively hippocampus-dependent memory measures like short-delay retention, long-delay retention and discriminability and percent hippocampal volume. No significant correlation with measures related to executive processes was found. In addition, percent amygdala volume was not related to any of these measures. Our data advance previous findings reported in studies of brain-damaged individuals in a large and homogeneous young healthy sample and are important for theories on the neural basis of episodic memory.
海马体对陈述性记忆过程的重要性已得到确凿证实。然而，健康受试者的陈述性记忆表现与海马体体积之间的相关性问题仍存在争议。本研究的目的是更详细地探究这种关系。为此，50名健康的年轻男性参与者进行了加利福尼亚言语学习测试。通过对高分辨率3D磁共振图像进行手动分割来评估海马体体积。我们发现，诸如短延迟记忆、长延迟记忆和辨别力等假定依赖海马体的记忆指标与海马体体积百分比之间存在显著正相关。未发现与执行过程相关的指标存在显著相关性。此外，杏仁核体积百分比与这些指标均无关。我们的数据在一个大规模且同质的年轻健康样本中推进了先前在脑损伤个体研究中报告的结果，并且对情景记忆神经基础的理论具有重要意义。
