Dept of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA.
Am J Clin Pathol. 2013 Jan;139(1):55-61. doi: 10.1309/AJCPO8VTSK3HRNUT.
To assess the diagnostic accuracy of histopatho-logic and cytopathologic examination (HCE) of Aspergillus species (spp), we performed an 11-year retrospective review to correlate surgical/cytology cases with a diagnosis of Aspergillus spp with their concurrent fungal culture results. Diagnostic accuracy was defined as the percentage of cases with culture-proven Aspergillus spp divided by the number of cases diagnosed as Aspergillus spp on HCE that had growth on fungal culture. Ninety surgical/cytology cases with concurrent fungal culture were reviewed, 58 of which grew a fungal organism. Of these 58 cases, 45 grew an Aspergillus spp, whereas 13 grew an organism other than Aspergillus spp, including both common (Scedosporium, Fusarium, and Paecilomyces spp) and uncommon mimickers (Trichosporon loubieri), resulting in a diagnostic accuracy of 78%. The low diagnostic accuracy indicates that several fungal organisms can morphologically mimic Aspergillus spp and can only be distinguished by fungal culture and DNA sequencing.
为了评估组织病理学和细胞病理学检查（HCE）对曲霉菌属（spp）的诊断准确性，我们进行了一项为期 11 年的回顾性研究，将手术/细胞学病例与曲霉菌属的诊断与同期真菌培养结果相关联。诊断准确性定义为经培养证实的曲霉菌属病例数除以 HCE 诊断为曲霉菌属且真菌培养有生长的病例数的百分比。共回顾了 90 例有同期真菌培养的手术/细胞学病例，其中 58 例培养出真菌。在这 58 例中，45 例培养出曲霉菌属，而 13 例培养出非曲霉菌属的真菌，包括常见的（枝孢菌属、镰刀菌属和拟青霉属）和罕见的模拟物（罗氏毛孢子菌），导致诊断准确性为 78%。低诊断准确性表明，几种真菌在形态上可以模拟曲霉菌属，只能通过真菌培养和 DNA 测序来区分。
