Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin 150086, China.
Mol Biol Rep. 2013 Apr;40(4):3389-94. doi: 10.1007/s11033-012-2416-z. Epub 2012 Dec 28.
Published data on the association between microRNA-499 (miR-499) rs3746444 T>C polymorphism and cancer susceptibility are inconclusive. To derive a more precise estimation of this relationship, a comprehensive meta-analysis was performed on nine published studies, with a total sample of 4,794 cases and 5,971 controls. Overall, no significant association was found between miR-499 polymorphism and cancer risk after all studies were pooled into the meta-analysis. However, in the subgroup analysis by ethnicity, significant association with an increased risk was found in Asian (CC vs. TT: OR = 1.439, 95 % CI = 1.118-1.852, P = 0.005, p-heterogeneity = 0.116). Moreover, in the the subgroup analysis by cancer type, this SNP was associated with an increased risk of breast cancer in the recessive model (OR = 1.077, 95 % CI = 1.008-1.151, P = 0.028, p-heterogeneity = 0.125). Our findings support the view that miR-499 rs3746444 T>C polymorphism is associated with breast cancer and the C allele can increase cancer susceptibility in Asian.
已发表的关于 microRNA-499（miR-499）rs3746444 T>C 多态性与癌症易感性之间的关联的数据尚无定论。为了更准确地评估这种关系，对 9 项已发表的研究进行了综合荟萃分析，共有 4794 例病例和 5971 例对照。总体而言，在荟萃分析中合并所有研究后，miR-499 多态性与癌症风险之间没有显著关联。然而，按种族亚组分析，发现亚洲人群中存在与风险增加相关的显著关联（CC 与 TT：OR = 1.439，95 % CI = 1.118-1.852，P = 0.005，p 异质性 = 0.116）。此外，按癌症类型的亚组分析，该 SNP 与隐性模型中乳腺癌的风险增加相关（OR = 1.077，95 % CI = 1.008-1.151，P = 0.028，p 异质性 = 0.125）。我们的研究结果支持这样的观点，即 miR-499 rs3746444 T>C 多态性与乳腺癌有关，C 等位基因可增加亚洲人群的癌症易感性。
