Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110001, People's Republic of China.
Mol Biol Rep. 2013 Apr;40(4):3003-13. doi: 10.1007/s11033-012-2372-7. Epub 2013 Jan 6.
MicroRNAs (miRNAs) are a class of new non-coding RNA, which may play a more important role in the pathogenesis of human cancers. Rs2910164 in miR-146a and rs3746444 in miR-499 are shown to be associated with increased/decreased cancer risk. We performed a meta-analysis to systematically summarize the possible association. We retrieved the relevant articles from PubMed databases. Studies were selected using specific inclusion and exclusion criteria. ORs and 95% CIs were calculated to access the strength of association between microRNA polymorphism and cancer risk. All analyses were performed using the Stata software. Twenty-nine studies were included in this meta-analysis. There were not significant associations between miR-146a rs2910164 and miR-499 rs3746444 polymorphisms with overall cancer risk. In the subgroup analysis by ethnicity, significantly affected cancer risks were found among Asians for both rs2910164 (GC vs. GG: OR = 0.89, 95% CI = 0.82-0.96; CC vs. GG: OR = 0.80, 95% CI = 0.66-0.97; GC + CC vs. GG: OR = 0.86, 95% CI = 0.76-0.97; C vs. G: OR = 0.91, 95% CI = 0.82-1.00) and rs3746444 (GG + AG vs. AA: OR = 1.21, 95% CI = 1.00-1.46). In the tumor type subgroup analysis, rs2910164 C allele decreased the risk of hepatocellular carcinoma (C vs. G: OR = 0.89, 95% CI = 0.80-1.00) and cervical squamous cell carcinoma (C vs. G: OR = 0.72, 95% CI = 0.62-0.84). The rs2910164 in miR-146a and the rs3746444 in miR-499 are likely to be associated with cancer risk.
MicroRNAs (miRNAs) 是一类新的非编码 RNA，它们可能在人类癌症的发病机制中发挥更重要的作用。miR-146a 中的 rs2910164 和 miR-499 中的 rs3746444 已被证明与癌症风险的增加/降低有关。我们进行了一项荟萃分析，以系统总结可能的关联。我们从 PubMed 数据库中检索了相关文章。使用特定的纳入和排除标准选择研究。使用 OR 和 95%CI 计算来评估 miRNA 多态性与癌症风险之间的关联强度。所有分析均使用 Stata 软件进行。这项荟萃分析共纳入 29 项研究。miR-146a rs2910164 和 miR-499 rs3746444 多态性与总体癌症风险之间没有显著关联。按种族进行亚组分析时，发现亚洲人群中这两个位点的 rs2910164（GC 与 GG：OR=0.89，95%CI=0.82-0.96；CC 与 GG：OR=0.80，95%CI=0.66-0.97；GC+CC 与 GG：OR=0.86，95%CI=0.76-0.97；C 与 G：OR=0.91，95%CI=0.82-1.00）和 rs3746444（GG+AG 与 AA：OR=1.21，95%CI=1.00-1.46）多态性与癌症风险显著相关。在肿瘤类型亚组分析中，rs2910164 的 C 等位基因降低了肝细胞癌（C 与 G：OR=0.89，95%CI=0.80-1.00）和宫颈鳞状细胞癌（C 与 G：OR=0.72，95%CI=0.62-0.84）的风险。miR-146a 中的 rs2910164 和 miR-499 中的 rs3746444 可能与癌症风险相关。
