Laboratory of Lymphocyte Signalling and Development, The Babraham Institute Babraham, UK.
Front Immunol. 2012 Dec 26;3:398. doi: 10.3389/fimmu.2012.00398. eCollection 2012.
Understanding the mechanisms by which signal transduction pathways mediate changes in RNA abundance requires the examination of the fate of RNA from its transcription to its degradation. Evidence suggests that RNA abundance is partly regulated by post-transcriptional mechanisms affecting RNA decay and this in turn is modulated by some of the same signaling pathways that control transcription. Furthermore, the translation of mRNA is a key regulatory step that is influenced by signal transduction. These processes are regulated, in part, by RNA-binding proteins (RBPs) which bind to sequence-specific RNA elements. The function of RBPs is controlled and co-ordinated by phosphorylation. Based on the current literature we hypothesize that RBPs may be a point of convergence for the activity of different kinases such as phosphoinositide-3-kinase and mitogen-activated protein kinase which regulate RBP localization and function.
理解信号转导途径介导 RNA 丰度变化的机制需要检查 RNA 从转录到降解的命运。有证据表明，RNA 的丰度部分受到影响 RNA 降解的转录后机制的调节，而这反过来又受到控制转录的一些相同信号通路的调节。此外，mRNA 的翻译是受信号转导影响的关键调节步骤。这些过程部分受到 RNA 结合蛋白 (RBP) 的调节，RBP 与序列特异性 RNA 元件结合。RBP 的功能受磷酸化控制和协调。基于目前的文献，我们假设 RBP 可能是不同激酶（如磷酸肌醇-3-激酶和丝裂原活化蛋白激酶）活性的汇聚点，这些激酶调节 RBP 的定位和功能。
