孕妇血清叶酸水平与血汞浓度的关系。
Relation between serum folate status and blood mercury concentrations in pregnant women.
机构信息
Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, Korea.
出版信息
Nutrition. 2013 Mar;29(3):514-8. doi: 10.1016/j.nut.2012.08.012. Epub 2012 Dec 28.
OBJECTIVE
To evaluate the relation between maternal serum folate status and blood mercury in pregnant Korean women.
METHODS
The nutritional status of folate and the blood mercury concentration were measured in pregnant Korean women who participated in a multicenter prospective study from 2006 through 2011. We analyzed existing blood mercury data based on serum folate status at two gestational time points (mid and late pregnancy, n = 1105 and 841, respectively).
RESULTS
Serum folate concentrations in pregnant women were negatively associated with blood mercury concentrations at mid and late pregnancy (P trend = 0.012 and 0.002, respectively). A general linear model developed after adjusting for covariates indicated a significant negative association between the two at mid and late pregnancy.
CONCLUSION
We found a negative association between serum folate and blood mercury concentrations in pregnant Korean women.
目的
评估孕妇血清叶酸状况与血汞之间的关系。
方法
对参加 2006 年至 2011 年多中心前瞻性研究的韩国孕妇进行叶酸营养状况和血汞浓度检测。我们根据两次妊娠中期（n=1105）和妊娠晚期（n=841）的血清叶酸状况对现有的血汞数据进行了分析。
结果
孕妇血清叶酸浓度与妊娠中期和晚期的血汞浓度呈负相关（P 趋势分别为 0.012 和 0.002）。在调整了协变量后建立的一般线性模型表明，妊娠中期和晚期两者之间存在显著的负相关关系。
结论
我们发现韩国孕妇血清叶酸与血汞浓度之间呈负相关。
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