铟作为中心金属可增强苯并卟啉衍生物的光敏效果。
Indium as a central metal enhances the photosensitizing efficacy of benzoporphyrin derivatives.
作者信息
Saenz Courtney, Ethirajan Manivannan, Iacobucci Gary, Pandey Ankit, Missert Joseph R, Dobhal Mahabeer P, Pandey Ravindra K
机构信息
Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
出版信息
J Porphyr Phthalocyanines. 2011 Nov;15(11n12):1310. doi: 10.1142/S1088424611004282.
Abstract
Compared to benzoporphyrin derivative-dimethyl ester (BPD-DME) and its 8-(1'-hexyloxy)ethyl analog the corresponding In(III) complexes showed enhanced in vitro photosensitizing efficacy in Colon26 tumor cells, which could be due to their higher singlet oxygen producing ability. In both organic (methanol) and aqueous Bovine Calf Serum (17% BCS) solutions the metalated analogs were significantly more stable than the parent photosensitizers. Presence of Indium as a central metal gave 13-25 nm hypsochromic shift to the long wavelength absorption band with reduced absorption and fluorescence intensity. The insertion of metal did not produce any difference in intracellular localization of the photosensitizers and were mainly localized in mitochondria.
摘要
与苯并卟啉衍生物二甲基酯（BPD-DME）及其8-(1'-己氧基)乙基类似物相比，相应的铟（III）配合物在Colon26肿瘤细胞中显示出增强的体外光敏疗效，这可能归因于它们更高的单线态氧产生能力。在有机（甲醇）和牛犊血清（17% BCS）水溶液中，金属化类似物均比母体光敏剂稳定得多。作为中心金属的铟的存在使长波长吸收带发生13 - 25 nm的紫移，同时吸收和荧光强度降低。金属的插入并未使光敏剂的细胞内定位产生任何差异，且主要定位于线粒体中。
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