Ghosh Sagar, Ashcraft Keith
Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, 15355 Lambda Dr, San Antonio, TX-78245, USA.
Front Biosci (Elite Ed). 2013 Jan 1;5(2):461-78. doi: 10.2741/e628.
Obesity is a growing epidemic all over the world that by virtue of inducation of a chronic, low-grade, and systemic inflammation leads to an increased risk of a number of diseases, including cancer. IL-6 an important cytokine in the increased risk to cancer in obese patients mainly because of its pro-inflammatory activity. Some data suggest that IL-6 might increase the risk of certain cancers such as those that originate from breast, liver, prostate, colon, and esophagus. A better understanding of the regulation and role of IL-6 in obesity-associated cancer is required to develop effective therapeutic approaches.
肥胖是一种在全球范围内日益流行的疾病，由于其引发慢性、低度全身性炎症，导致包括癌症在内的多种疾病风险增加。白细胞介素-6（IL-6）是肥胖患者患癌风险增加中的一种重要细胞因子，主要因其促炎活性。一些数据表明，IL-6可能会增加某些癌症的风险，如源自乳腺、肝脏、前列腺、结肠和食管的癌症。为了开发有效的治疗方法，需要更好地了解IL-6在肥胖相关癌症中的调节作用。
