Enayatjazi Mansour, Esfarjani Fahimeh, Reisi Jalil, Moshtaghian Seyed Jamal
Department of Sport Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran.
Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran.
Int J Prev Med. 2022 Mar 12;13:38. doi: 10.4103/ijpvm.IJPVM_315_20. eCollection 2022.
This study aimed to determine the effect of garlic consumption and endurance training on the serum levels of some pro-inflammatory and anti-inflammatory cytokines in female mice with breast cancer.
This study is an experimental research randomly conducted on 32 female BALB/c mice divided into 4 equal groups ( = 8), including: Cancer Control (CC), Garlic Supplementation (GS), Endurance Training (ET), Endurance Training + Garlic Supplementation (ET + GS). One million cancerous cells were injected to all mice's upper right thigh using the subcutaneous injection method. Exercise groups performed endurance training for 8 weeks (5 days a week.(Garlic supplement groups received 1 ml of the garlic extract orally per kilogram of body weight. The control groups -were not given any task, activity or exercise during the research. At the end of the research, all the mice were anesthetized, and their blood samples were collected.
The period of 8-week simultaneous endurance exercise and consumption of garlic supplement significantly decreased the serum level of interleukin-6 ( = 75 = 0.00), interleukin-8 ( = 97.9 = 0.00), and interleukin-17 ( = 95.7 = 0.00), and increased the serum level of interleukin-10 ( = 50.4 = 0.00).
Along with other existing methods, reduction of inflammatory factors, endurance exercises and consumption of garlic supplement have been proved to be an extremely effective treatment for breast cancer patients.
本研究旨在确定食用大蒜和耐力训练对患有乳腺癌的雌性小鼠血清中某些促炎和抗炎细胞因子水平的影响。
本研究为实验性研究，随机选取32只雌性BALB/c小鼠，平均分为4组（每组 = 8只），包括：癌症对照组（CC）、大蒜补充组（GS）、耐力训练组（ET）、耐力训练 + 大蒜补充组（ET + GS）。采用皮下注射法将100万个癌细胞注射到所有小鼠的右上大腿。运动组进行8周的耐力训练（每周5天）。大蒜补充组每千克体重口服1毫升大蒜提取物。对照组在研究期间不给予任何任务、活动或运动。研究结束时，将所有小鼠麻醉并采集血样。
为期8周的耐力运动与食用大蒜补充剂同时进行，显著降低了白细胞介素 - 6（ = 75 = 0.00）、白细胞介素 - 8（ = 97.9 = 0.00）和白细胞介素 - 17（ = 95.7 = 0.00）的血清水平，并提高了白细胞介素 - 10（ = 50.4 = 0.00）的血清水平。
与其他现有方法一起，减少炎症因子、进行耐力运动和食用大蒜补充剂已被证明是乳腺癌患者极其有效的治疗方法。
