Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, 15-054 Bialystok, Poland.
Department of Biotechnology, Medical University of Bialystok, 15-089 Bialystok, Poland.
Int J Mol Sci. 2023 Feb 18;24(4):4145. doi: 10.3390/ijms24044145.
Obesity is a chronic, progressive and relapsing disease that produces many adverse health, social and economic effects. The aim of the study was to analyse the concentrations of selected proinflammatory parameters in the saliva of obese and normal body weight individuals. The study included 116 people divided into two groups: the study group ( = 75, subjects with obesity) and the control group ( = 41, individuals with normal body weight). Bioelectrical impedance analysis was performed, and saliva samples were collected from all study participants to determine the concentrations of selected proinflammatory adipokines and cytokines. Statistically significantly higher concentrations of MMP-2, MMP-9 and IL-1β were found in the saliva of obese women compared to women with normal body weight. Furthermore, statistically significantly higher concentrations of MMP-9, IL-6 and resistin were observed in the saliva of obese men compared to men with normal body weight. Higher concentrations of selected proinflammatory cytokines and adipokines were found in the saliva of obese individuals compared to individuals with normal body weight. It is likely that higher concentrations of MMP-2, MMP-9 and IL-1β can be detected in the saliva of obese women compared to non-obese women, while higher concentrations of MMP-9, IL-6 and resistin can be found in the saliva of obese men compared to non-obese men, which suggests that further research to confirm our observations and determine the mechanisms of development of metabolic complications associated with obesity depending on gender is needed.
肥胖是一种慢性、进行性和复发性疾病，会产生许多不良的健康、社会和经济影响。本研究旨在分析肥胖和正常体重个体唾液中选定促炎参数的浓度。该研究纳入了 116 人，分为两组：研究组（=75 人，肥胖受试者）和对照组（=41 人，体重正常个体）。对所有研究参与者进行生物电阻抗分析，并采集唾液样本以确定选定促炎脂肪因子和细胞因子的浓度。与体重正常的女性相比，肥胖女性的唾液中 MMP-2、MMP-9 和 IL-1β 的浓度明显更高。此外，与体重正常的男性相比，肥胖男性的唾液中 MMP-9、IL-6 和抵抗素的浓度明显更高。与体重正常的个体相比，肥胖个体的唾液中发现了更高浓度的选定促炎细胞因子和脂肪因子。与非肥胖女性相比，肥胖女性的唾液中可能检测到更高浓度的 MMP-2、MMP-9 和 IL-1β，而与非肥胖男性相比，肥胖男性的唾液中可能检测到更高浓度的 MMP-9、IL-6 和抵抗素，这表明需要进一步研究来证实我们的观察结果，并确定与性别相关的肥胖相关代谢并发症的发展机制。
