Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland.
Menopause. 2013 Jun;20(6):667-76. doi: 10.1097/gme.0b013e318278eec1.
A proportion of women experience depressive and anxiety symptoms and/or disorders in connection with the menopausal transition. Estrogen-only therapy has been reported to have beneficial effects on mental health, but the effects of combined hormone therapy (HT) on mental health are less clear. We studied the associations between HT use and psychopathology in perimenopausal and postmenopausal women.
Data on women who participated in the Health 2000 Survey and the National FINRISK Surveys in Finland were analyzed.
An association between current HT use and psychiatric diagnosis in the previous 12 months was found. In addition, HT use was associated with recent self-reported diagnosis of depression and with depressed mood (FINRISK), as well as with major depressive disorder and anxiety disorder (Health 2000). Associations with the following symptoms were found: nervousness, frightening thoughts, nightmares, and headache (FINRISK), feelings of depression (FINRISK and Health 2000), and unhappiness (Health 2000). No differences between different routes of administration or types of HT emerged.
Current use of HT in perimenopausal and postmenopausal women is associated with worse psychological well-being and mental health than in women not using HT. It is important to identify women in need of psychiatric support at the time of the menopausal transition.
一部分女性在更年期过渡期间会经历抑郁和焦虑症状和/或障碍。据报道，雌激素单独治疗对心理健康有有益影响，但联合激素治疗（HT）对心理健康的影响则不太明确。我们研究了 HT 使用与围绝经期和绝经后妇女精神病理学之间的关系。
分析了参加芬兰健康 2000 调查和国家 FINRISK 调查的女性的数据。
发现当前 HT 使用与过去 12 个月的精神科诊断之间存在关联。此外，HT 使用与近期自我报告的抑郁和抑郁情绪（FINRISK）以及重度抑郁症和焦虑症（健康 2000）相关。与以下症状相关：紧张、恐惧的想法、噩梦和头痛（FINRISK）、抑郁感（FINRISK 和健康 2000）和不快乐（健康 2000）。不同给药途径或 HT 类型之间没有差异。
围绝经期和绝经后正在使用 HT 的女性的心理健康和心理幸福感比不使用 HT 的女性差。在更年期过渡期间，识别需要精神支持的女性非常重要。
