Weber D A, Sanders C C
Department of Medical Microbiology, Creighton University School of Medicine, Omaha, Nebraska 68178.
Antimicrob Agents Chemother. 1990 Jan;34(1):156-8. doi: 10.1128/AAC.34.1.156.
The ability of various beta-lactamase inhibitors to induce class I beta-lactamases was assessed. Clavulanate was the most active compound, inducing Morganella morganii, Aeromonas caviae, and Enterobacter aerogenes over a broad concentration range and Citrobacter freundii, Pseudomonas aeruginosa, and Serratia marcescens at high concentrations. Disk approximation tests paralleled these results, with clavulanate, but not sulbactam or tazobactam, antagonizing the activity of several beta-lactams against these organisms.
评估了各种β-内酰胺酶抑制剂诱导I类β-内酰胺酶的能力。克拉维酸是最具活性的化合物，在较宽的浓度范围内可诱导摩根氏摩根菌、豚鼠气单胞菌和产气肠杆菌产生β-内酰胺酶，在高浓度时可诱导弗氏柠檬酸杆菌、铜绿假单胞菌和粘质沙雷氏菌产生β-内酰胺酶。纸片扩散试验的结果与此相符，克拉维酸可拮抗几种β-内酰胺类药物对这些菌的活性，而舒巴坦或他唑巴坦则不能。
