Roy Josée, Bédard Christian, Moreau Maxim, Sauvé Frédéric
Vétoquinol Canada, 2000 ch. Georges, Lavaltrie, Quebec J5T 3S5, Canada.
Can Vet J. 2012 Jul;53(7):762-6.
The efficacy of Oridermyl(®) (acaricidal/antibiotic/antifungal/anti-inflammatory ointment) and Revolution(®) (selamectin spot-on) was compared in a blinded randomized study on 24 adult cats with otoacariasis. Twelve cats were treated once daily for 10 d with Oridermyl(®) and 12 cats were treated on Day 0 with Revolution(®). Otitis was assessed with cytological counts of mean number of bacteria and yeast on Days 0 and 10, and scored clinically every other day. All auricular secretions were removed for mite count on Day 10. On Day 0, cytological examination confirmed the presence of secondary bacterial (24/24) and fungal (21/24) infections. No live mites were observed otoscopically after Day 4 and in auricular secretions at Day 10 in both groups. On Day 10, secondary infections were resolved for all cats treated with Oridermyl(®) but were present in all cats treated with Revolution(®). Improvement in clinical signs of otitis over time was superior in the Oridermyl(®) group (P < 0.001).
在一项针对24只患有耳螨病的成年猫的双盲随机研究中，比较了Oridermyl（杀螨/抗生素/抗真菌/抗炎软膏）和Revolution（赛拉菌素滴剂）的疗效。12只猫每天用Oridermyl治疗一次，持续10天，12只猫在第0天用Revolution治疗。在第0天和第10天通过细菌和酵母菌平均数的细胞学计数评估耳炎，并每隔一天进行临床评分。在第10天清除所有耳部分泌物以进行螨虫计数。在第0天，细胞学检查证实存在继发性细菌感染（24/24）和真菌感染（21/24）。两组在第4天后耳镜检查均未观察到活螨，且在第10天耳部分泌物中也未观察到活螨。在第10天，所有用Oridermyl治疗的猫的继发性感染均得到解决，但所有用Revolution治疗的猫仍存在继发性感染。Oridermyl组耳炎临床症状随时间的改善情况更优（P < 0.001）。
