MSD Animal Health Innovation GmbH, Research Antiparasitics, Zur Propstei, 55270, Schwabenheim, Germany.
Clinvet, Uitsig Road, Bainsvlei, Bloemfontein, 9338, South Africa.
Parasit Vectors. 2018 Nov 19;11(1):595. doi: 10.1186/s13071-018-3167-z.
The efficacy of the fixed combination of fluralaner plus moxidectin for the treatment of Otodectes cynotis infestations was evaluated in cats after topical application.
Sixteen cats experimentally infested with O. cynotis were allocated randomly to two groups of 8 cats each. One group was treated topically with the fixed combination of fluralaner plus moxidectin at the minimum dose rate of 40 mg fluralaner and 2 mg moxidectin/kg body weight. The other group was treated with physiological saline solution. Before and 14 and 28 days after treatment the ears of all cats were examined otoscopically for live mites and for the amount of debris and cerumen. Twenty-eight days after treatment, the cats were sedated and had both ears flushed to obtain the total number of live mites per animal. Efficacy was calculated, based on the results of the ear flushing, by comparing mean live mite counts in the fluralaner plus moxidectin treated group versus the saline group.
A single topical application of the fixed combination of fluralaner plus moxidectin to cats reduced the mean mite counts by 100% (P < 0.001) by 28 days after treatment. No mites were visible during otoscopic examination at either 14 or 28 days after treatment. All fluralaner plus moxidectin treated cats had less ceruminous exudate 28 days after treatment compared to pre-treatment and 14 days after treatment. No treatment related adverse events were observed in any cats enrolled in the study.
Single topical application of the fixed combination of fluralaner plus moxidectin was highly effective against O. cynotis infestations in cats.
在猫科动物中，评估了氟虫腈加莫昔克丁固定组合用于治疗耳痒螨感染的疗效。
将 16 只实验性感染耳痒螨的猫随机分为两组，每组 8 只。一组猫用氟虫腈加莫昔克丁固定组合按最低剂量率 40mg 氟虫腈和 2mg 莫昔克丁/千克体重进行局部治疗。另一组猫用生理盐水处理。在治疗前和治疗后 14 天和 28 天，对所有猫的耳朵进行耳镜检查，以检查活螨、碎屑和耳垢的数量。在治疗后 28 天，给猫镇静并冲洗两只耳朵，以获得每只动物的活螨总数。根据耳冲洗的结果，通过比较氟虫腈加莫昔克丁治疗组和盐水组的平均活螨计数，计算疗效。
猫科动物单次局部应用氟虫腈加莫昔克丁固定组合可使螨的平均数量在治疗后 28 天减少 100%（P<0.001）。在治疗后 14 天或 28 天，耳镜检查时均未见螨虫。与治疗前和治疗后 14 天相比，所有接受氟虫腈加莫昔克丁治疗的猫在治疗后 28 天的耳垢分泌物均较少。在研究中，没有观察到任何与治疗相关的不良事件。
单次局部应用氟虫腈加莫昔克丁固定组合对猫科动物耳痒螨感染具有高度疗效。
