Kaur Satinder, Singh Parminder, Indu Verma, Singla Gaurav
Department of Biochemistry, Dayanand Medical College & Hospital, Ludhiana, 141 001 Punjab India.
Indian J Clin Biochem. 2012 Jan;27(1):94-6. doi: 10.1007/s12291-011-0184-5. Epub 2011 Dec 25.
The present work was undertaken to study interrelation of Fibrinogen, Lp(a) and LVMI in Type II diabetes patients with or without nephropathy. 100 Type II Diabetic patients attending OPD/IPD of DMC&H, Ludhiana were included. They were divided in two groups. Group I: 50 patients without microalbuminuria (MAU). Group II: 50 patients with MAU. Fibrinogen (Clauss method), Lp(a) and MAU were estimated on Multichannel Autoanalyzer Hitachi-911 (Roche). LVMI was estimated by echocardiography using formula of Devereux and Reicheck. Type II diabetes patients with MAU had significantly raised levels of Fibrinogen, Lp(a), and LVMI as compared to normoalbuminuric diabetics (P < 0.01). Group II patients had positive correlation between Lp(a) and LVMI but no relation between Fibrinogen and LVMI. MAU, marker of microangiopathy, is associated with higher Fibrinogen and Lp(a) levels. This becomes basis of increase cardiovascular risk as demonstrated by higher mean LVMI in Group II patients.
本研究旨在探讨伴有或不伴有肾病的II型糖尿病患者中纤维蛋白原、脂蛋白(a)与左心室质量指数(LVMI)之间的相互关系。纳入了100例在卢迪亚纳DMC&H门诊/住院部就诊的II型糖尿病患者。他们被分为两组。第一组：50例无微白蛋白尿(MAU)的患者。第二组：50例有MAU的患者。使用日立911多通道自动分析仪（罗氏公司）检测纤维蛋白原（Clauss法）、脂蛋白(a)和MAU。采用Devereux和Reicheck公式通过超声心动图估算LVMI。与正常白蛋白尿的糖尿病患者相比，有MAU的II型糖尿病患者的纤维蛋白原、脂蛋白(a)和LVMI水平显著升高（P<0.01）。第二组患者的脂蛋白(a)与LVMI呈正相关，但纤维蛋白原与LVMI之间无相关性。MAU作为微血管病变的标志物，与较高的纤维蛋白原和脂蛋白(a)水平相关。这成为心血管风险增加的基础，如第二组患者较高的平均LVMI所示。
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