Kumar Jha Pravin, Ete Tony, Malviya Amit, Kumar Das Chandra, Saha Swapan Kumar, Nath Dhanjit, Kapoor Manish, Mishra Animesh
Department of Cardiology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Mawdiangdiang, Shillong, India.
J Clin Med Res. 2017 Oct;9(10):838-843. doi: 10.14740/jocmr2785w. Epub 2017 Sep 1.
Previous studies have shown that microalbuminuria (MAU) is an independent risk factor for cardiovascular diseases in diabetics, hypertensive patients and in the general population. However, the correlation of MAU with the severity of coronary artery disease (CAD) in non-diabetic patients has not been addressed in detail. This study aimed to investigate the relationship between MAU and severity of angiographically confirmed CAD in non-diabetic patients.
This was a cross-sectional study, which included 90 non-diabetic patients with documented CAD by coronary angiography. The ratio of urine albumin to creatinine was used to define MAU and severity of CAD was estimated using SYNTAX score. Patients were divided into two groups: group I that included patients without MAU and group II that included patients with MAU.
Out of 90 non-diabetic CAD patients, 62 (68.9%) were in group I (MAU negative) and 28 (31.1%) were in group II (MAU positive). There was statistically significant difference in the median SYNTAX score between the groups (21 vs. 28, P < 0.001). The prevalences of double vessel CAD and triple vessel CAD were significantly higher in MAU positive group. There was a strong relationship between the presence of MAU and the extent and complexity of CAD (r = 0.094; P < 0.001).
Thus, we conclude that patients with MAU have more severe angiographically detected CAD than those without MAU, and MAU exhibits a significant association with the presence and severity of CAD.
既往研究表明，微量白蛋白尿（MAU）是糖尿病患者、高血压患者及普通人群心血管疾病的独立危险因素。然而，MAU与非糖尿病患者冠状动脉疾病（CAD）严重程度之间的相关性尚未得到详细探讨。本研究旨在调查非糖尿病患者中MAU与经血管造影证实的CAD严重程度之间的关系。
这是一项横断面研究，纳入了90例经冠状动脉造影证实患有CAD的非糖尿病患者。尿白蛋白与肌酐的比值用于定义MAU，CAD严重程度采用SYNTAX评分进行评估。患者分为两组：I组为无MAU的患者，II组为有MAU的患者。
在90例非糖尿病CAD患者中，62例（68.9%）属于I组（MAU阴性），28例（31.1%）属于II组（MAU阳性）。两组间SYNTAX评分中位数存在统计学显著差异（21对28，P<0.001）。MAU阳性组双支血管CAD和三支血管CAD的患病率显著更高。MAU的存在与CAD的范围和复杂性之间存在密切关系（r=0.094；P<0.001）。
因此，我们得出结论，与无MAU的患者相比，有MAU的患者经血管造影检测出的CAD更严重，且MAU与CAD的存在及严重程度显著相关。
