Department of Geriatric Behavioral Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Psychogeriatrics. 2012 Dec;12(4):226-34. doi: 10.1111/j.1479-8301.2012.00406.x.
There have been no reports on the prevalence of dementia among the old-old people in Japan.
We studied the old-old population in Kurihara, northern Japan. Analysis 1 of Participants 1 (n=590) was performed to evaluate the prevalence of dementia and dementing diseases by intensive evaluation including MRI. Analysis 2 aimed to determine a good indicator for detecting 'suspected dementia condition' based on the Long-Term Care Insurance index. Analysis 3 of Participants 2 (n=3915) aimed to estimate the prevalence of 'suspected dementia condition'.
In Analysis 1, 73 people (12.4%) were diagnosed with dementia. The most common cause was Alzheimer's disease with cerebrovascular disease. In Analysis 2, level I of the Impairment Level of Dementia was found to be a good indicator of 'suspected dementia condition'. In Analysis 3, the overall estimated prevalence of 'suspected dementia condition' was 23.6%. In men, the ratio increased gradually from 75 to 87 years old to about 20%, increased to 40% at the age of 88 and became stable thereafter. In contrast, in women, the ratio increased from 75 to 95+ years old, reaching about 70%.
The prevalence was higher than that reported previously. There was a difference between the sexes: an 'age-related' increase occurred in men and an 'ageing-related' increase in women. Alzheimer's disease with cerebrovascular disease was the most common cause, which coincided with the previous findings of individuals aged 65 years and older; however, the ratio of mixed dementia was greater.
目前尚无关于日本高龄老年人痴呆症患病率的报告。
我们对日本北部栗原的高龄老年人进行了研究。分析 1(参与者 1,n=590)旨在通过包括 MRI 在内的强化评估来评估痴呆症和痴呆疾病的患病率。分析 2 旨在确定基于长期护理保险指数检测“疑似痴呆状况”的良好指标。分析 3(参与者 2,n=3915)旨在估计“疑似痴呆状况”的患病率。
在分析 1 中,73 人(12.4%)被诊断为痴呆症。最常见的病因是阿尔茨海默病合并血管性疾病。在分析 2 中,发现一级痴呆损害程度是“疑似痴呆状况”的良好指标。在分析 3 中,“疑似痴呆状况”的总估计患病率为 23.6%。在男性中,该比例从 75 岁到 87 岁逐渐增加到约 20%,在 88 岁时增加到 40%,此后保持稳定。相比之下,在女性中,该比例从 75 岁到 95 岁以上增加到约 70%。
患病率高于之前的报告。存在性别差异:男性呈“年龄相关”增加,女性呈“老龄化相关”增加。阿尔茨海默病合并血管性疾病是最常见的病因,与之前报告的 65 岁及以上人群的结果一致;然而,混合性痴呆的比例更大。