Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford, CA 94305, USA.
Curr Opin Cell Biol. 2013 Apr;25(2):195-9. doi: 10.1016/j.ceb.2012.12.001. Epub 2012 Dec 29.
Cells are highly organized structures. In addition to membrane delimited organelles, proteins and RNAs can organize themselves into specific domains. Some examples include stress granules and subnuclear bodies. This level of organization is essential for the correct execution of multiple processes in the cell, ranging from cell signaling to assembly of structures such as the ribosomes. Here we will review evidence that noncoding RNAs play a critical role in the establishment and regulation of these domains. The unique abilities of RNA to mark the genome in a gene-specific and condition-specific manner and to serve as tethers nominate them as ideal molecular address codes.
细胞是高度组织化的结构。除了膜分隔的细胞器外，蛋白质和 RNA 也可以自行组织成特定的结构域。应激颗粒和核内小体就是其中的例子。这种组织水平对于细胞中多种过程的正确执行至关重要，这些过程包括细胞信号转导以及核糖体等结构的组装。在这里，我们将回顾非编码 RNA 在这些结构域的建立和调控中发挥关键作用的证据。RNA 具有在基因和条件特异性方式上标记基因组的独特能力，并可作为连接物，这使它们成为理想的分子地址代码。
