头颈部癌症放射性感音神经性听力损失的特征：系统评价。
Characteristics of radiation-induced sensorineural hearing loss in head and neck cancer: a systematic review.
机构信息
Division of Otolaryngology-Head and Neck Surgery, The Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada.
出版信息
Head Neck. 2013 Nov;35(11):1662-8. doi: 10.1002/hed.23201. Epub 2012 Dec 22.
BACKGROUND
Patients receiving radiotherapy (RT) for head and neck tumors are at risk of developing sensorineural hearing loss. The objective of this study was to analyze the literature regarding sensorineural hearing loss after RT for head and neck cancer.
METHODS
Seven databases were searched to identify eligible studies. Eligible articles were independently assessed for quality by 2 authors.
RESULTS
Fourteen articles were evaluated. There was considerable heterogeneity among studies. The reported incidence of sensorineural hearing loss (SNHL) varied from 0% to 85% for the speech frequencies and from 27% to 95% for high frequencies. As the follow-up increased, an increase in the incidence of SNHL was observed. The minimum cochlear dose reported to be a risk factor for SNHL was 45 Gy.
CONCLUSIONS
High quality literature in the topic is lacking. Radiation-induced SNHL is progressive, permanent, and dose-dependent. Total dose and follow-up time are important factors affecting incidence rates.
背景
接受头颈部肿瘤放射治疗（RT）的患者有发生感音神经性听力损失的风险。本研究的目的是分析头颈部癌症放射治疗后感音神经性听力损失的文献。
方法
检索了七个数据库以确定合格的研究。两名作者独立评估合格文章的质量。
结果
评估了 14 篇文章。研究之间存在很大的异质性。报告的感音神经性听力损失（SNHL）发生率在言语频率为 0%至 85%之间，高频频率为 27%至 95%之间。随着随访时间的增加，SNHL 的发生率增加。报道的导致 SNHL 的最小耳蜗剂量为 45Gy。
结论
该主题缺乏高质量的文献。放射引起的 SNHL 是进行性的、永久性的和剂量依赖性的。总剂量和随访时间是影响发病率的重要因素。
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