Wungcharoen Prem, Prayongrat Anussara, Tangjaturonrasme Napadon
Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Int Arch Otorhinolaryngol. 2025 Jul 3;29(2):1-9. doi: 10.1055/s-0045-1805045. eCollection 2025 Apr.
Radiotherapy is the primary treatment for nasopharyngeal carcinoma. Radiation exposure to the cochlea and middle ear can cause hearing loss. To develop a multivariable normal tissue complication probability (NTCP) model to predict the risk of hearing impairment in nasopharyngeal cancer patients based on clinical and radiation dosimetry features and to identify the key factors associated with hearing loss. A retrospective review of 229 patients was conducted. We recorded the audiometry and presence of middle ear effusion (MEE) and compared findings before and after therapy. The factors included age, gender, signs and symptoms at presentation, tumor staging, prescribed dose at the tumor and high-risk nodal region, cochlea, and concurrent chemotherapy treatment. The model was formulated using multivariate logistic regression. Age of more than 50 years, high primary staging, and dose at the cochlea > 43 Gy were major risk factors for sensorineural hearing loss. The final NTCP model for hearing loss comprised age and cochlea dose with an area under the curve (AUC) of 0.644; the predicted risk ranged from 15.84 to 44.52%. Locally advanced disease and cochlea dose greater than 44 Gy were risk factors for MEE; the predicted risk ranged from 20.42 to 51.99%. Age over 50, T stages 3 and 4, and > 43 Gy dose to the cochlea were significantly associated with an increased risk of sensorineural hearing loss and MEE. The developed NTCP model provides information to predict these risks, aiding in treatment planning and decision-making to avoid complications.
放射治疗是鼻咽癌的主要治疗方法。耳蜗和中耳受到辐射照射可导致听力损失。
建立一个多变量正常组织并发症概率(NTCP)模型,以根据临床和放射剂量学特征预测鼻咽癌患者听力损害的风险,并确定与听力损失相关的关键因素。
对229例患者进行了回顾性研究。我们记录了听力测定结果和中耳积液(MEE)的情况,并比较了治疗前后的结果。因素包括年龄、性别、就诊时的体征和症状、肿瘤分期、肿瘤和高危淋巴结区域、耳蜗的处方剂量以及同步化疗治疗情况。该模型采用多变量逻辑回归构建。
年龄超过50岁、原发分期高以及耳蜗剂量>43 Gy是感音神经性听力损失的主要危险因素。最终的听力损失NTCP模型包括年龄和耳蜗剂量,曲线下面积(AUC)为0.644;预测风险范围为15.84%至44.52%。局部晚期疾病和耳蜗剂量大于44 Gy是MEE的危险因素;预测风险范围为20.42%至51.99%。
年龄超过50岁、T3和T4期以及耳蜗剂量>43 Gy与感音神经性听力损失和MEE风险增加显著相关。所建立的NTCP模型为预测这些风险提供了信息,有助于治疗计划的制定和决策以避免并发症。