Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri.
Head Neck. 2013 Nov;35(11):1669-78. doi: 10.1002/hed.23202. Epub 2012 Dec 22.
The purpose of this review was to provide biological concepts of head and neck cancer metastasis. To attain this goal, we analyzed peer-reviewed articles related to head and neck cancer metastasis obtained though PubMed and archived articles. Articles related to the biologic principles of head and neck cancer metastasis were reviewed and summarized. As locoregional control has improved for patients with head and neck cancer, rates of distant metastasis have not decreased. As patients live longer, many will die of complications related to the development of disease at sites below the clavicles. Emerging evidence now suggests a more complicated framework of metastatic behavior for head and neck cancer. Here, we review the role of regional lymph nodes in containing advanced head and neck cancer, evidence for active as opposed to passive tumor cell metastasis, and clinical implications these concepts have on both treatment of head and neck cancer and future research.
本次综述旨在提供头颈部癌症转移的生物学概念。为了实现这一目标，我们分析了通过 PubMed 获得的有关头颈部癌症转移的同行评议文章和存档文章。我们对与头颈部癌症转移的生物学原理相关的文章进行了回顾和总结。随着头颈部癌症患者的局部区域控制得到改善，远处转移的比率并没有降低。随着患者寿命的延长，许多人将死于锁骨以下部位疾病发展相关的并发症。目前有新的证据表明，头颈部癌症的转移行为存在更复杂的框架。在这里，我们回顾了区域淋巴结在控制晚期头颈部癌症中的作用，以及肿瘤细胞主动转移而非被动转移的证据，以及这些概念对头颈部癌症的治疗和未来研究的临床意义。
