结构对氧化生成的 C3'-胸腺嘧啶基自由基导致的 DNA 损伤产物的影响。
The impact of structure on oxidatively generated DNA damage products resulting from the C3'-thymidinyl radical.
机构信息
Department of Chemistry, The University of Toledo, 2801 W. Bancroft St., Toledo, OH 43606-3390, USA.
出版信息
Chembiochem. 2013 Jan 21;14(2):187-90. doi: 10.1002/cbic.201200723. Epub 2012 Dec 28.
PMID:23280951
Abstract
What's the damage? Trapping the C3'-thymidinyl radical in biologically significant architectures delivers both the repaired oligomer and 1-(2'-deoxy-β-D-threo-pentofuranosyl)thymidine-containing substrates. The stereoselectivity of the reduction was found to be dependent upon the DNA structure.
摘要
造成了什么损害？在具有生物学意义的结构中捕获 C3'-胸腺嘧啶基自由基，可得到修复的寡聚物和含有 1-(2'-脱氧-β-D-赤式-戊呋喃糖基)胸腺嘧啶的底物。还原的立体选择性被发现取决于 DNA 结构。
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