Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada.
Pediatr Pulmonol. 2013 Apr;48(4):317-23. doi: 10.1002/ppul.22739. Epub 2012 Dec 31.
MicroRNAs (miRNAs) constitute a large group of small (∼22 nucleotides), non-coding RNA sequences that are highly conserved among animals, plants and microorganisms, suggesting that microRNAs represent a highly conserved and important regulatory mechanism. They have been demonstrated to play an important role in gene regulation. Recently, miRNAs have become a major focus of interest for research in organ development. Research focusing on the potential role of microRNAs during lung development is slowly starting to emerge. A number of miRNAs have been demonstrated to play important roles during early and late lung development. Several studies have begun to profile miRNA expression at various stages of lung development and this article provides an overview of the various miRNAs that have been implicated in lung organogenesis.
MicroRNAs (miRNAs) 是一大类小的（约 22 个核苷酸）、非编码 RNA 序列，在动物、植物和微生物中高度保守，这表明 microRNAs 代表了一种高度保守和重要的调控机制。它们已被证明在基因调控中发挥重要作用。最近，miRNAs 已成为器官发育研究的主要关注点。关于 microRNAs 在肺发育过程中潜在作用的研究也逐渐开始出现。许多 miRNAs 已被证明在肺的早期和晚期发育过程中发挥重要作用。一些研究已经开始对肺发育的各个阶段的 miRNA 表达进行分析，本文综述了参与肺器官发生的各种 miRNAs。
