Sun Mengge, Zhou Xiaoya, Chen Lili, Huang Shishu, Leung Victor, Wu Nan, Pan Haobo, Zhen Wanxin, Lu William, Peng Songlin
Department of Spine Surgery, Shenzhen People's Hospital, Jinan University School of Medicine, Shenzhen 518020, China; Department of Orthopaedics and Traumatology, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong; Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Biomed Res Int. 2016;2016:1652417. doi: 10.1155/2016/1652417. Epub 2016 Mar 17.
MicroRNAs are involved in many cellular and molecular activities and played important roles in many biological and pathological processes, such as tissue formation, cancer development, diabetes, neurodegenerative diseases, and cardiovascular diseases. Recently, it has been reported that microRNAs can modulate the differentiation and activities of osteoblasts and osteoclasts, the key cells that are involved in bone remodeling process. Meanwhile, the results from our and other research groups showed that the expression profiles of microRNAs in the serum and bone tissues are significantly different in postmenopausal women with or without fractures compared to the control. Therefore, it can be postulated that microRNAs might play important roles in bone remodeling and that they are very likely to be involved in the pathological process of postmenopausal osteoporosis. In this review, we will present the updated research on the regulatory roles of microRNAs in osteoblasts and osteoclasts and the expression profiles of microRNAs in osteoporosis and osteoporotic fracture patients. The perspective of serum microRNAs as novel biomarkers in bone loss disorders such as osteoporosis has also been discussed.
微小RNA参与许多细胞和分子活动，并在许多生物学和病理过程中发挥重要作用，如组织形成、癌症发展、糖尿病、神经退行性疾病和心血管疾病。最近，有报道称微小RNA可调节成骨细胞和破骨细胞的分化及活性，而成骨细胞和破骨细胞是参与骨重塑过程的关键细胞。同时，我们和其他研究小组的结果表明，与对照组相比，绝经后有或无骨折的女性血清和骨组织中微小RNA的表达谱存在显著差异。因此，可以推测微小RNA可能在骨重塑中发挥重要作用，并且很可能参与绝经后骨质疏松症的病理过程。在这篇综述中，我们将介绍关于微小RNA在成骨细胞和破骨细胞中的调节作用以及在骨质疏松症和骨质疏松性骨折患者中微小RNA表达谱的最新研究。还讨论了血清微小RNA作为骨质疏松症等骨质流失疾病新型生物标志物的前景。
