职业性铅暴露对血清1,25-二羟维生素D水平的影响。

Effect of occupational lead exposure on serum 1,25-dihydroxyvitamin D levels.

作者信息

Mason H J, Somervaille L J, Wright A L, Chettle D R, Scott M C

机构信息

Occupational Medicine and Hygiene Laboratories, Health and Safety Executive, London, UK.

出版信息

Hum Exp Toxicol. 1990 Jan;9(1):29-34. doi: 10.1177/096032719000900107.

DOI:10.1177/096032719000900107

PMID:2328144

Abstract

The effects of lead exposure on serum 1,25-dihydroxyvitamin D levels and calcium homeostasis have been studied in 63 males occupationally exposed to the metal in the UK. The exposure indices used were blood lead, reflecting short-term exposure, and an in vivo X-ray fluorescence measurement of tibia lead which reflects cumulative lead exposure. Serum 1,25-dihydroxyvitamin D levels were higher than those in a referent population, who were non-occupationally exposed to lead, and were correlated with both blood lead and tibia lead. Multiple regression analysis suggested that blood lead was the variable responsible for the increase in serum 1,25-dihydroxyvitamin D. There were no other abnormalities in calcium metabolism associated with the degree of lead exposure.

摘要

在英国，对63名职业性接触铅的男性进行了研究，以探讨铅暴露对血清1,25 - 二羟基维生素D水平和钙稳态的影响。所使用的暴露指标为血铅（反映短期暴露）和胫骨铅的体内X射线荧光测量值（反映累积铅暴露）。血清1,25 - 二羟基维生素D水平高于未职业性接触铅的对照人群，且与血铅和胫骨铅均相关。多元回归分析表明，血铅是导致血清1,25 - 二羟基维生素D升高的变量。与铅暴露程度相关的钙代谢没有其他异常情况。