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用于1300nm以上生物成像的短波近红外发射型GdPO:Nd诊疗探针。

Short-wave near-infrared emissive GdPO:Nd theranostic probe for bioimaging beyond 1300 nm.

作者信息

Yang Qiuhua, Li Xiaolong, Xue Zhenluan, Li Youbin, Jiang Mingyang, Zeng Songjun

机构信息

College of Physics and Information Science, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of the Ministry of Education, Synergetic Innovation Center for Quantum Effects and Applications, Hunan Normal University Changsha 410081 Hunan China

出版信息

RSC Adv. 2018 Apr 4;8(23):12832-12840. doi: 10.1039/c7ra12864a. eCollection 2018 Apr 3.

DOI:10.1039/c7ra12864a
PMID:35541268
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9079334/
Abstract

The optical probes working in the second near-infrared (NIR-II) window have attracted increasing research interest for their advantages of high tissue penetration depth, low autofluorescence, and unprecedentedly improved imaging sensitivity and spatial resolution. Therefore, it is of great significance to design a new nanoplatform by integration of NIR-II optical imaging and drug delivery functions. Herein, a multifunctional nanoplatform based on GdPO:Nd yolk-shell sphere was developed for dual-modal NIR-II/X-ray bioimaging and pH-responsive drug delivery. The NIR-II bioimaging and real-time tracking presented that these probes were mainly accumulated in liver and spleen. Moreover, owing to the large X-ray absorption coefficient of Gd, these probes are successfully used as superior X-ray imaging agents than iobitridol. The toxicity assessments demonstrate the low biotoxicity of the GdPO:Nd spheres in living animals. More importantly, apart from the excellent dual-modal bioimaging, these yolk-shell-structured probes were also used as ideal nanotransducer for pH-responsive drug delivery of doxorubicin (DOX). These findings open up the opportunity of designing theranostic nanoplatform with integration of imaging-based diagnosis and therapy.

摘要

工作于第二近红外（NIR-II）窗口的光学探针因其具有高组织穿透深度、低自发荧光以及前所未有的成像灵敏度和空间分辨率等优势而吸引了越来越多的研究兴趣。因此，通过整合NIR-II光学成像和药物递送功能来设计一种新型纳米平台具有重要意义。在此，基于GdPO:Nd核壳球开发了一种多功能纳米平台，用于双模态NIR-II/X射线生物成像和pH响应性药物递送。NIR-II生物成像和实时追踪表明这些探针主要积聚在肝脏和脾脏中。此外，由于Gd具有较大的X射线吸收系数，这些探针作为X射线成像剂比碘海醇更具优势。毒性评估证明了GdPO:Nd球在活体动物中的低生物毒性。更重要的是，除了出色的双模态生物成像外，这些核壳结构的探针还被用作阿霉素（DOX）pH响应性药物递送的理想纳米换能器。这些发现为设计集成基于成像的诊断和治疗的治疗诊断纳米平台提供了机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/461b/9079334/b7451af11495/c7ra12864a-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/461b/9079334/95645d8fb7e0/c7ra12864a-s1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/461b/9079334/98a2172ff82a/c7ra12864a-f5.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/461b/9079334/fadcce6ffb19/c7ra12864a-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/461b/9079334/b7451af11495/c7ra12864a-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/461b/9079334/95645d8fb7e0/c7ra12864a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/461b/9079334/af00daf282f4/c7ra12864a-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/461b/9079334/01d59b8377fb/c7ra12864a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/461b/9079334/59f48c9d5c7c/c7ra12864a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/461b/9079334/98a2172ff82a/c7ra12864a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/461b/9079334/7bad778825f4/c7ra12864a-f6.jpg
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