Gastrointestinal Research Laboratory, Department of Medicine, and Departments of *Pathology and †Biomathematical Sciences, Mount Sinai School of Medicine, New York, New York, U.S.A.
Inflamm Bowel Dis. 1997 Winter;3(4):254-9.
: Expression of the mucin-associated sialyl-Tn (STn) antigen is correlated with malignant progression in the colon. In patients with longstanding ulcerative colitis (UC) who never exhibited colonic dysplasia, STn was expressed in fewer than 15% of nondysplastic surveillance colonoscopic biopsies, whereas matched patients who developed colon cancer expressed STn in >40% of previous surveillance biopsies, often several years before the first detection of dysplasia. Since no study has systematically examined STn expression in Crohn's colitis, we performed immunohistochemical staining with monoclonal antibody TKH2 on 110 surgical specimens from 59 patients with Crohn's colitis or ileocolitis. Forty percent of specimens expressed STn antigen. STn was preferentially expressed in specimens of the left colon, regardless of whether the patient had segmental left-sided disease or pancolitis. Specimens with active inflammation manifested increased STn expression, regardless of location in the colon or whether the patient had segmental disease or pancolitis. The enhanced expression of STn in Crohn's colitis compared with UC may reflect important differences in local cytokine profiles between the two inflammatory bowel diseases.
黏蛋白相关唾液酸化 Tn（STn）抗原的表达与结肠恶性进展相关。在长期患有溃疡性结肠炎（UC）但从未出现结肠异型增生的患者中，STn 在不到 15%的非异型增生性结肠镜监测活检中表达，而发生结肠癌的匹配患者在 >40%的先前监测活检中表达 STn，通常在首次检测到异型增生之前数年。由于尚无研究系统地检查克罗恩病中的 STn 表达，我们使用单克隆抗体 TKH2 对 59 例克罗恩病或回结肠疾病患者的 110 例手术标本进行了免疫组织化学染色。40%的标本表达 STn 抗原。STn 优先在左半结肠的标本中表达，无论患者是否患有节段性左侧疾病或全结肠炎。无论炎症位于结肠何处，以及患者是否患有节段性疾病或全结肠炎，具有活性炎症的标本均表现出 STn 表达增加。与 UC 相比，克罗恩病中 STn 的增强表达可能反映了两种炎症性肠病之间局部细胞因子谱的重要差异。
