Karlén P, Young E, Broström O, Löfberg R, Tribukait B, Ost K, Bodian C, Itzkowitz S
Division of Gastroenterology, Department of Medicine, Söder Hospital, Karolinska Institute, Stockholm, Sweden.
Gastroenterology. 1998 Dec;115(6):1395-404. doi: 10.1016/s0016-5085(98)70018-6.
BACKGROUND & AIMS: Expression of the mucin-associated carbohydrate antigen sialyl-Tn (STn) and DNA aneuploidy has each been shown to correlate with malignant transformation in patients with sporadic colon cancer and in those with ulcerative colitis (UC). This study aimed to determine how STn expression topographically and temporally relates to aneuploidy and neoplasia in patients with long-standing UC.
Twenty-six patients enrolled in a cancer surveillance program were studied, and 1691 mucosal specimens from repeated colonoscopies and colectomies were assessed in a standardized, prospective fashion for the presence of dysplasia, aneuploidy, and STn antigen.
STn was expressed in 47% of specimens from 6 patients who underwent colectomy for dysplasia and 7% of specimens from 6 well-matched patients who underwent surgery for medical intractability. Seven other patients who never developed dysplasia or aneuploidy expressed STn in 6% of biopsy specimens. STn expression was independent of aneuploidy in colons both with and without dysplasia. Of 5 patients with aneuploidy but without dysplasia, 4 expressed STn earlier than aneuploidy.
In UC, STn antigen and DNA aneuploidy are independent markers of neoplastic transformation. Determination of STn expression may complement dysplasia and aneuploidy for identification of risk for colonic neoplasia in UC.
黏蛋白相关碳水化合物抗原唾液酸-Tn（STn）的表达和DNA非整倍体均已被证明与散发性结肠癌患者以及溃疡性结肠炎（UC）患者的恶性转化相关。本研究旨在确定长期UC患者中STn表达在空间和时间上如何与非整倍体及肿瘤形成相关。
对参加癌症监测项目的26例患者进行研究，以标准化的前瞻性方式对来自重复结肠镜检查和结肠切除术的1691份黏膜标本进行评估，以确定是否存在发育异常、非整倍体和STn抗原。
6例因发育异常接受结肠切除术患者的标本中，47%表达STn；6例因内科治疗无效接受手术的匹配良好患者的标本中，7%表达STn。另外7例从未发生发育异常或非整倍体的患者，其活检标本中有6%表达STn。在有和没有发育异常的结肠中，STn表达均独立于非整倍体。在5例有非整倍体但无发育异常的患者中，4例STn表达早于非整倍体。
在UC中，STn抗原和DNA非整倍体是肿瘤转化的独立标志物。测定STn表达可能补充发育异常和非整倍体，用于识别UC患者发生结肠肿瘤的风险。
