Itzkowitz S H, Marshall A, Kornbluth A, Harpaz N, McHugh J B, Ahnen D, Sachar D B
Gastrointestinal Research Laboratory, Mount Sinai School of Medicine, New York, New York, USA.
Gastroenterology. 1995 Aug;109(2):490-7. doi: 10.1016/0016-5085(95)90337-2.
BACKGROUND & AIMS: Expression of the mucin-associated carbohydrate antigen sialosyl-Tn (STn) correlates with malignant transformation in sporadic colonic neoplasms. The aim of this study was to analyze STn antigen expression in patients with long-standing ulcerative colitis (UC).
STn antigen was assessed by immunohistochemistry in archival tissues. Study A was a retrospective chronological case-control study. Serial surveillance colonoscopic biopsy specimens without inflammation or dysplasia were analyzed in 7 patients who developed colon cancer and in 8 controls who did not develop colon cancer. Study B analyzed the anatomic distribution of STn expression in 17 cancer-bearing (case) and 6 cancer-free (control) colectomy specimens from patients with UC. In some colectomy specimens, STn was compared with aneuploidy, which was determined by flow cytometry.
In study A, among the 7 patients with UC who developed cancer, 6 patients (86%) expressed STn in at least one prior nondysplastic surveillance biopsy specimen from the same site. Only 3 of 8 control patients (38%) expressed STn. In study B, STn was expressed in 40 of 82 specimens (49%) from cancer-bearing colons but only 8 of 62 specimens (13%) from cancer-free colons. STn was expressed in most aneuploid areas but was also found in diploid, nondysplastic mucosa.
STn antigen seems to be a promising marker of cancer risk in patients with UC.
黏蛋白相关碳水化合物抗原唾液酸-Tn（STn）的表达与散发性结肠肿瘤的恶性转化相关。本研究旨在分析长期溃疡性结肠炎（UC）患者中STn抗原的表达情况。
通过免疫组织化学对存档组织中的STn抗原进行评估。研究A是一项回顾性按时间顺序排列的病例对照研究。对7例患结肠癌的患者和8例未患结肠癌的对照者的连续监测结肠镜活检标本进行分析，这些标本无炎症或发育异常。研究B分析了17例患癌（病例）和6例未患癌（对照）的UC患者结肠切除标本中STn表达的解剖分布。在一些结肠切除标本中，将STn与通过流式细胞术确定的非整倍体进行比较。
在研究A中，7例患癌的UC患者中，6例（86%）在来自同一部位的至少一份先前无发育异常的监测活检标本中表达STn。8例对照患者中只有3例（38%）表达STn。在研究B中，82份来自患癌结肠的标本中有40份（49%）表达STn，但62份来自无癌结肠的标本中只有8份（13%）表达STn。STn在大多数非整倍体区域表达，但也在二倍体、无发育异常的黏膜中发现。
STn抗原似乎是UC患者癌症风险的一个有前景的标志物。
