从白皮松中得到的具有独特的 5/11/5/6/5 环系和前所未有的双环[8.2.1]十三烷核的非典型的三萜内酯假海松烷酮。

Pseudolarenone, an unusual nortriterpenoid lactone with a fused 5/11/5/6/5 ring system featuring an unprecedented bicyclo[8.2.1]tridecane core from Pseudolarix amabilis.

机构信息

Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China.

出版信息

Chem Commun (Camb). 2013 Feb 11;49(12):1187-9. doi: 10.1039/c2cc37742j.

Abstract

A phytochemical investigation of the cone of Pseudolarix amabilis led to the isolation of pseudolarenone (), a structurally novel pentacyclic (5/11/5/6/5) nortriterpenoid lactone with an unprecedented carbon skeleton featuring a unique bicyclo[8.2.1]tridecane core. Its structure and absolute configurations were elucidated by spectroscopic analysis and single crystal X-ray diffraction (CuK(α)).

摘要

对白皮松球果的化学成分研究导致了伪白蜡素（）的分离，这是一种结构新颖的五环（5/11/5/6/5）倍半萜内酯，具有前所未有的碳骨架，具有独特的双环[8.2.1]十三烷核心。通过光谱分析和单晶 X 射线衍射（CuK(α)）确定了其结构和绝对构型。