From the University of Kent, Chatham Maritime, Kent, United Kingdom.
World Allergy Organ J. 2010 Oct;3(10):245-9. doi: 10.1097/WOX.0b013e3181f8daa5.
Hypoxia-inducible factor 1 (HIF-1) is a transcription complex that plays a pivotal role in cellular adaptation to hypoxic conditions. The role of this factor in inflammatory reactions associated with infections and allergies has recently become evident. In this review we summarize our current knowledge concerning the accumulation and role of HIF-1 in Toll-like receptor-mediated and allergic inflammation. The differential molecular mechanisms used to stabilize this protein in various settings and its ability to support both proinflammatory and angiogenic responses suggest important functional roles in both innate immune responses and allergies. Importantly, the HIF-1 transcription complex is activated in human basophils during IgE-mediated inflammatory responses. It is involved in VEGF expression and subsequent promotion of angiogenesis and in controlling energy metabolism.
缺氧诱导因子 1（HIF-1）是一种转录复合物，在细胞适应缺氧环境中发挥关键作用。该因子在与感染和过敏相关的炎症反应中的作用最近已变得明显。在这篇综述中，我们总结了目前关于 HIF-1 在 Toll 样受体介导的和过敏性炎症中的积累和作用的知识。在各种情况下稳定这种蛋白质的不同分子机制及其支持促炎和血管生成反应的能力表明，它在先天免疫反应和过敏中具有重要的功能作用。重要的是，HIF-1 转录复合物在 IgE 介导的炎症反应期间在人嗜碱性粒细胞中被激活。它参与 VEGF 的表达和随后的血管生成促进，并控制能量代谢。
