非甾体抗炎药敏感患者药物摄入和支气管痉挛之间的时间延迟。

The time delay between drug intake and bronchospasm for nonsteroidal antiinflammatory drugs sensitive patients.

机构信息

From the 1Vilnius University, Faculty of Medicine, Lithuania; 2Vilnius University Emergency hospital, Lithuania; 3Vilnius Gediminas Technical University, Faculty of Fundamental Sciences, Lithuania; 4Vilnius University hospital Santariskiu klinikos, Lithuania.

出版信息

World Allergy Organ J. 2010 Dec;3(12):266-70. doi: 10.1097/WOX.0b013e3181fdfc5f.

DOI:10.1097/WOX.0b013e3181fdfc5f

PMID:23282984

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3651119/

Abstract

A study was performed to assess the time between drug intake and drug induced hypersensitivity reaction for patients sensitive to nonsteroidal antiinflammatory drugs (NSAID) in clinical patient history and after oral provocation tests. Drug hypersensitivity ENDA questionnaires were filled for the patients with suspected sensitivity to NSAID. Oral provocation tests were performed with suspected NSAID according to the ENDA/EAACI recommendations. There were 76 patients with history of hypersensitivity reactions after use of NSAID enrolled in the study. Recorded were 154 hypersensitivity reactions to NSAID in the clinical history. In the clinical history median time of immediate reactions (76 cases, 81%) between drug intake and bronchospasm was 20 minutes [15-30 minutes]. Median time of nonimmediate reactions (18 cases, 19%) was 120 minutes [120-390 minutes]. There were 50 oral provocation tests performed, 14 of them (28%) were positive. Median time between drug intake and immediate reactions (8; 57% of cases) was 22.5 minutes [20-30 minutes] and median time of nonimmediate reactions (6; 43% of cases) was 167.5 minutes [125-206.25 minutes]. Time delay between drug intake and bronchospasm in the clinical history and after oral provocation test was not statistically different.

摘要

一项研究评估了在临床病史和口服激发试验后，对非甾体抗炎药（NSAID）敏感的患者，药物摄入与药物诱导的过敏反应之间的时间间隔。对疑似对 NSAID 敏感的患者填写了药物过敏 ENDA 问卷。根据 ENDA/EAACI 建议，对疑似 NSAID 进行口服激发试验。共有 76 例 NSAID 使用后过敏反应史的患者纳入研究。在临床病史中记录了 154 例 NSAID 过敏反应。在临床病史中，立即反应（76 例，81%）的药物摄入和支气管痉挛之间的中位数时间为 20 分钟[15-30 分钟]。非立即反应（18 例，19%）的中位数时间为 120 分钟[120-390 分钟]。进行了 50 次口服激发试验，其中 14 次（28%）呈阳性。立即反应（8；8 例的 57%）的药物摄入和中位数时间为 22.5 分钟[20-30 分钟]，非立即反应（6；8 例的 43%）的中位数时间为 167.5 分钟[125-206.25 分钟]。在临床病史和口服激发试验后，药物摄入与支气管痉挛之间的延迟时间无统计学差异。