Association between metabolic syndrome and premicroalbuminuria among Iranian women with Polycystic Ovary Syndrome: a case control study.

OBJECTIVE

The aim of this study was to assess the association between premicroalbuminuria and metabolic syndrome in women with Polycystic Ovary Syndrome (PCOS).

METHODS

In this case - control study, we analyzed the medical records of 78 women (mean age ±SD was 27.2± 2.5 years) with PCOS and 63 controls (mean age ±SD was 26.9±2.4 years) from an endocrinology outpatient center of Buali university hospital Qazvin city in Iran during 2008 to 2010. Anthropometric characteristics, Albumin/Creatinine Ratio (ACR), Lipid profile, Liver enzyme concentration and occurrence of metabolic syndrome were compared between the two groups. Premicroalbuminuria was defined as ACR>7mg/g.

RESULTS

Premicroalbuminuria was found in 53.8% of PCOS and 33.3% of control group (p value=0.015). Patients with PCOS and premicroalbuminuria had higher serum levels of fasting insulin and glucose, blood pressure and more waist circumference compared to PCOS patients who had ACR<7mg/g. Fifty percent of patients with PCOS and ACR>7mg/g fulfilled criteria of metabolic syndrome; whereas no case of metabolic syndrome was found in PCOS patients without premicroalbuminuria.

CONCLUSIONS

Premicroalbuminuria is more prevalent in patients with PCOS compared to normal individuals. Metabolic syndrome is more frequently seen in patients with PCOS and premicroalbuminuria against patients with ACR<7mg/g.