Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
World Allergy Organ J. 2009 Jul;2(7):138-43. doi: 10.1097/WOX.0b013e3181aed85c.
: Allergy is a serious problem affecting approximately 1 of 4 individuals. The symptoms with and without allergy etiology are often difficult to distinguish from each other without using an IgE antibody test. The aim of this study was to investigate the performance of a new point-of-care (POC) test for IgE antibodies to relevant allergens in Europe.
: IgE antibodies from children and adults with allergies recruited from allergy clinics in Sweden and Spain were analyzed for 10 allergens, suitable for the age groups, using the new POC test and ImmunoCAP laboratory test. The IgE antibody level best discriminating between positive and negative results (the cutoff point) for the different allergens of the POC test and the efficacy of the POC and the ImmunoCAP laboratory tests for diagnosing allergy compared with that of clinical diagnosis were investigated.
: The estimated cutoffs for the different allergens in the POC test ranged from 0.70 to 2.56 kUA/L. Taking into account all positive allergen results in a given patient, the POC test could identify 95% of the patients with allergies. Seventy-eight percent of the allergen-specific physicians' diagnoses were identified and 97% of the negative ones. Most allergens exhibited good performance, identifying about 80% of clinically relevant cases. However, dog, mugwort, and wall pellitory would benefit from improvement.
: The POC test will be a valuable adjunct in the identification or exclusion of patients with allergies and their most likely offending allergens, both in specialist and general care settings.
过敏是一个严重的问题，大约影响到每四个人中的一个。没有使用 IgE 抗体测试，有和没有过敏病因的症状往往难以区分。本研究旨在调查一种新的即时检测（POC）在欧洲针对相关过敏原的 IgE 抗体的性能。
使用新的 POC 测试和 ImmunoCAP 实验室测试，对来自瑞典和西班牙过敏诊所的过敏儿童和成人的 IgE 抗体进行分析，分析了 10 种适合年龄组的过敏原。研究了 POC 测试中不同过敏原的最佳区分阳性和阴性结果（截止值）的 IgE 抗体水平，以及 POC 和 ImmunoCAP 实验室测试诊断过敏的效果与临床诊断相比。
POC 测试中不同过敏原的估计截止值范围为 0.70 至 2.56 kUA/L。考虑到患者中所有阳性过敏原结果，POC 测试可以识别 95%的过敏患者。80%的过敏原特异性医生诊断被识别，97%的阴性诊断被识别。大多数过敏原表现出良好的性能，识别了约 80%的临床相关病例。然而，狗、艾蒿和墙荨麻需要改进。
POC 测试将是在专科和一般护理环境中识别或排除过敏患者及其最可能的过敏原的有价值的辅助手段。
