Wang L D, Lipkin M, Qui S L, Yang G R, Yang C S, Newmark H L
Institute of Henan Medical Sciences, Henan Medical University, Zhengzhou, People's Republic of China.
Cancer Res. 1990 May 1;50(9):2651-3.
The pattern of proliferation of epithelial cells in esophageal epithelium was studied by means of [3H]deoxythymidine labeling of esophageal epithelium in subjects from Huixian, Henan Province, China, a high-risk geographical region for esophageal cancer. Comparisons were made among patterns of cell proliferation observed in normal esophagus, in hyperplasia, in mild dysplasia, and in moderate dysplasia in a total of 118 subjects. The amount of cell proliferation observed was lowest in normal esophageal epithelium and increased progressively in subjects having hyperplasia, mild dysplasia, and moderate dysplasia. The location of proliferating cells was limited mainly to the base of the esophageal epithelium in normal esophagus, but expanded toward the surface of the esophageal lining in individuals with hyperplasia and dysplasia. The larger total numbers of proliferating cells in the esophageal epithelium and the progressive expansion of the proliferative compartment toward the epithelial surface found in hyperplasia and in dysplasia could both facilitate the screening of subjects for esophageal cancer risk and serve as intermediate biomarkers in prophylactic dietary or pharmacological intervention studies.
通过对来自中国河南省辉县（食管癌高发地区）的受试者食管上皮进行[3H]脱氧胸苷标记，研究了食管上皮中上皮细胞的增殖模式。对总共118名受试者的正常食管、增生、轻度发育异常和中度发育异常中观察到的细胞增殖模式进行了比较。观察到的细胞增殖量在正常食管上皮中最低，并在增生、轻度发育异常和中度发育异常的受试者中逐渐增加。增殖细胞的位置在正常食管中主要局限于食管上皮的底部，但在增生和发育异常的个体中向食管内衬表面扩展。在增生和发育异常中发现的食管上皮中增殖细胞总数较多以及增殖区向上皮表面的逐渐扩展，都有助于筛查食管癌风险受试者，并可作为预防性饮食或药物干预研究中的中间生物标志物。
