Yang G C, Lipkin M, Yang K, Wang G Q, Li J Y, Yang C S, Winawer S, Newmark H, Blot W J, Fraumeni J F
Cancer Institute, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
J Natl Cancer Inst. 1987 Dec;79(6):1241-6.
Histopathologic and tritiated thymidine labeling subjects were carried out on esophageal biopsy specimens of 44 human subjects with cytologic evidence of dysplasia from Linxian, People's Republic of China, a high-risk area for esophageal cancer. With the use of histopathologic criteria, 10 cases showed evidence of dysplasia, 20 hyperplasia, and 14 a near-normal morphology when compared with 21 normal cases studied previously from Jiaoxian, a low-risk area for esophageal cancer in the People's Republic of China. Significantly increased labeling indices were found in the esophageal mucosa of the dysplasia and hyperplasia subjects. There was a gradient of increased expansion in the basal layer of proliferating cells progressing from normal to hyperplasia to dysplasia, with the expansion twice as high in the epithelial cell lining in dysplasia when compared with the findings in the normal and near-normal groups. The correlation of proliferative abnormalities with the severity of precancerous lesions of the esophagus indicates that labeling studies may provide a sensitive adjunct to evaluate risk status and any modifications that might result from nutritional intervention.
对来自中国食管癌高发区林县的44例有细胞学异型增生证据的人体受试者的食管活检标本进行了组织病理学和氚标记胸腺嘧啶核苷标记研究。运用组织病理学标准，与之前研究的来自中国食管癌低发区胶县的21例正常病例相比，10例显示有异型增生证据，20例有增生，14例形态近乎正常。在异型增生和增生受试者的食管黏膜中发现标记指数显著增加。从正常到增生再到异型增生，增殖细胞基底层的扩张增加呈梯度变化，与正常组和近乎正常组相比，异型增生时上皮细胞内衬的扩张高出两倍。食管癌前病变严重程度与增殖异常之间的相关性表明，标记研究可能为评估风险状态以及营养干预可能产生的任何改变提供一种敏感的辅助手段。
