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德国高血压的患病率、治疗和控制情况是否发生了变化?一项针对 5 万名初级保健患者的临床流行病学研究。

Changes in the prevalence, treatment and control of hypertension in Germany? A clinical-epidemiological study of 50.000 primary care patients.

机构信息

Clinical Pharmacology Mannheim, Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim of the University of Heidelberg, Heidelberg, Germany.

出版信息

PLoS One. 2012;7(12):e52229. doi: 10.1371/journal.pone.0052229. Epub 2012 Dec 28.

Abstract

INTRODUCTION

Medical societies have developed guidelines for the detection, treatment and control of hypertension (HTN). Our analysis assessed the extent to which such guidelines were implemented in Germany in 2003 and 2001.

METHODS

Using standardized clinical diagnostic and treatment appraisal forms, blood pressure levels and patient questionnaires for 55,518 participants from the cross-sectional Targets and Essential Data for Commitment of Treatment (DETECT) study (2003) were analyzed. Physician's diagnosis of hypertension (HTN(doc)) was defined as coding hypertension in the clinical appraisal questionnaire. Alternative definitions used were physician's diagnosis or the patient's self-reported diagnosis of hypertension (HTN(doc,pat)), physician's or patient's self-reported diagnosis or a BP measurement with a systolic BP ≥ 140 mmHg and/or a diastolic BP ≥ 90 (HTN(doc,pat,bp)) and diagnosis according to the National Health and Nutrition Examination Survey (HTN(NHANES)). The results were compared with the similar German HYDRA study to examine whether changes had occurred in diagnosis, treatment and adequate blood pressure control (BP below 140/90 mmHg) since 2001. Factors associated with pharmacotherapy and control were determined.

RESULTS

The overall prevalence rate for hypertension was 35.5% according to HTN(doc) and 56.0% according to NHANES criteria. Among those defined by NHANES criteria, treatment and control rates were 56.0% and 20.3% in 2003, and these rates had improved from 55.3% and 18.0% in 2001. Significant predictors of receiving antihypertensive medication were: increasing age, female sex, obesity, previous myocardial infarction and the prevalence of comorbid conditions such as coronary heart disease (CHD), hyperlipidemia and diabetes mellitus (DM). Significant positive predictors of adequate blood pressure control were CHD and antihypertensive medication. Inadequate control was associated with increasing age, male sex and obesity.

CONCLUSIONS

Rates of treated and controlled hypertension according to NHANES criteria in DETECT remained low between 2001 and 2003, although there was some minor improvement.

摘要

简介

医学协会制定了高血压(HTN)的检测、治疗和控制指南。我们的分析评估了 2003 年和 2001 年德国实施这些指南的程度。

方法

使用标准化的临床诊断和治疗评估表,对来自横断面目标和治疗承诺的基本数据(DETECT)研究(2003 年)的 55518 名参与者的血压水平和患者问卷进行了分析。高血压的医生诊断(HTN(doc))定义为临床评估问卷中编码高血压。还使用了其他定义,即医生诊断或患者自我报告的高血压诊断(HTN(doc,pat))、医生或患者自我报告的诊断或收缩压≥140mmHg 和/或舒张压≥90mmHg 的血压测量值(HTN(doc,pat,bp))以及根据国家健康和营养检查调查(NHANES)的诊断(HTN(NHANES))。将结果与类似的德国 HYDRA 研究进行比较,以检查自 2001 年以来,诊断、治疗和血压控制(血压低于 140/90mmHg)是否发生变化。确定了与药物治疗和控制相关的因素。

结果

根据 HTN(doc)和 NHANES 标准,高血压的总体患病率分别为 35.5%和 56.0%。在根据 NHANES 标准定义的人群中,2003 年治疗和控制率分别为 56.0%和 20.3%,与 2001 年的 55.3%和 18.0%相比有所改善。接受抗高血压药物治疗的显著预测因素是:年龄增长、女性、肥胖、既往心肌梗死以及冠心病(CHD)、血脂异常和糖尿病(DM)等合并症的患病率。血压控制充分的显著正预测因素是 CHD 和抗高血压药物。血压控制不足与年龄增长、男性和肥胖有关。

结论

根据 DETECT 中的 NHANES 标准,2001 年至 2003 年间,经治疗和控制的高血压患病率仍然较低,尽管略有改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/817c/3532113/7e360ab38962/pone.0052229.g001.jpg

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