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秀丽隐杆线虫 THO 复合物对于有丝分裂细胞周期和发育是必需的。

The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development.

机构信息

Department of Molecular Biology, Centro Andaluz de Biología Molecular y Medicina Regenerativa, Universidad de Sevilla, Sevilla, Spain.

出版信息

PLoS One. 2012;7(12):e52447. doi: 10.1371/journal.pone.0052447. Epub 2012 Dec 20.

DOI:10.1371/journal.pone.0052447
PMID:23285047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3527488/
Abstract

THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological relevance of THO during development and in adult organisms. Using Caenorhabditis elegans as a model system we show that the THO complex is essential for mitotic genome integrity and the developmentally regulated mitotic cell cycles occurring during late postembryonic stages.

摘要

THO 是一种保守的真核复合物，参与 mRNP 的生物发生和 RNA 输出，在有丝分裂和减数分裂中防止转录和 RNA 介导的基因组不稳定性方面发挥重要作用。在哺乳动物中，THO 对于胚胎发生是必需的，这限制了我们在发育中和成年生物中分析 THO 的生理相关性的能力。使用秀丽隐杆线虫作为模型系统，我们表明 THO 复合物对于有丝分裂基因组完整性和在胚胎后期发生的发育调控的有丝分裂细胞周期是必需的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df3/3527488/dc58085cfd2e/pone.0052447.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df3/3527488/1520e2766e23/pone.0052447.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df3/3527488/8735e5becc72/pone.0052447.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df3/3527488/563925b06109/pone.0052447.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df3/3527488/dc58085cfd2e/pone.0052447.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df3/3527488/1520e2766e23/pone.0052447.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df3/3527488/8735e5becc72/pone.0052447.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df3/3527488/563925b06109/pone.0052447.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df3/3527488/dc58085cfd2e/pone.0052447.g004.jpg

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