Yamada M
First Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan.
Crit Care Med. 1990 May;18(5):509-14. doi: 10.1097/00003246-199005000-00010.
We studied the effects of coenzyme Q10 (CoQ10) on pulmonary function and chemical mediators in a canine model of hemorrhagic shock. One group received 10 mg/kg of CoQ10 before hemorrhage. During the study, percent change from baseline of peak airway pressure, total lung compliance of the lung and chest wall, and blood lactate levels appeared to be significantly smaller in dogs pretreated with CoQ10 than in controls. Furthermore, CoQ10 was found to maintain blood histamine levels and to attenuate the increase in leukotriene C4. The mechanism of the beneficial effects of CoQ10 in hemorrhagic shock is presently unknown, but our data suggest that it may be useful in the treatment of hemorrhagic shock.
我们在犬失血性休克模型中研究了辅酶Q10（CoQ10）对肺功能和化学介质的影响。一组在出血前接受10mg/kg的CoQ10。在研究过程中，与对照组相比，用CoQ10预处理的犬的气道峰值压力、肺和胸壁的总肺顺应性以及血乳酸水平相对于基线的变化百分比似乎显著更小。此外，发现CoQ10可维持血组胺水平并减轻白三烯C4的增加。目前尚不清楚CoQ10在失血性休克中产生有益作用的机制，但我们的数据表明它可能对失血性休克的治疗有用。
