An Feng-xian, Wang Xiao, Liu Wen, Gao Yan-li, Ma Jin-long, Xu Xing-xin, Chen Shi-ming, Yang Min
Department of Pathology, Provincial Hospital Affiliated to Shandong University, Jinan, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2012 Dec;34(6):590-4. doi: 10.3881/j.issn.1000-503X.2012.06.010.
To study the expressions and clinical significances of p-extracellular regulated kinase(P-ERK)1/2 and matrix metalloproteinase-9(MMP-9)in cervical squamous cell carcinoma.
The expressions of P-ERK1/2 and MMP-9 in 30 cases with chronic cervicitis, 45 cases with cervical intraepithelial neoplasia (CIN), and 58 cases with cervical squamous cell carcinoma were detected by immunohistochemical method.
The positive rates of P-ERK1/2 and MMP-9 in chronic cervicitis, CIN, and cervical squamous cell carcinoma were 0 and 0, 28.9% and 24.4%, 77.6% and 65.5%, respectively, showing significant differences among these three groups (χ(2)= 54.393,p=0.003;χ(2)=40.968,p=0.005). The positive rates of P-ERK1/2 and MMP-9 in patients at clinical stages 2-3, at G3, with lymphatic metastasis, or with a tumor diameter greater than 4 cm were significantly higher than those at clinical stage 1(p=0.015,p=0.002), at G1-G2(p=0.013,p=0.017), without lymphatic metastasis (p=0.017,p=0.021), or with a tumor diameter less or equal than 4 cm in cervical squamous cell carcinoma(p=0.008,p=0.004). There was a positive correlation between P-ERK1/2 and MMP-9 in cervical squamous cell carcinoma (χ(2)=8.955,p=0.006).
The expressions of P-ERK1/2 and MMP-9 increase gradually with the progression of cervical squamous cell carcinoma. The over expressions of P-ERK1/2 and MMP-9 may promote the infiltration of cervical squamous cell carcinoma and lymphatic metastasis, druing which these two enzymes may exert their effects in a synergistic manner.
研究磷酸化细胞外调节蛋白激酶（P-ERK）1/2和基质金属蛋白酶-9（MMP-9）在宫颈鳞状细胞癌中的表达及临床意义。
采用免疫组织化学方法检测30例慢性宫颈炎、45例宫颈上皮内瘤变（CIN）和58例宫颈鳞状细胞癌中P-ERK1/2和MMP-9的表达。
慢性宫颈炎、CIN和宫颈鳞状细胞癌中P-ERK1/2和MMP-9的阳性率分别为0和0、28.9%和24.4%、77.6%和65.5%，三组间差异有统计学意义（χ²=54.393，p=0.003；χ²=40.968，p=0.005）。宫颈鳞状细胞癌临床分期2-3期、G3级、有淋巴转移或肿瘤直径大于4 cm患者中P-ERK1/2和MMP-9的阳性率明显高于临床分期1期（p=0.015，p=0.002）、G1-G2级（p=0.013，p=0.017）、无淋巴转移（p=0.017，p=0.021）或肿瘤直径小于或等于4 cm者（p=0.008，p=0.004）。宫颈鳞状细胞癌中P-ERK1/2与MMP-9呈正相关（χ²=8.955，p=0.006）。
P-ERK1/2和MMP-9的表达随宫颈鳞状细胞癌的进展而逐渐升高。P-ERK1/2和MMP-9的过表达可能促进宫颈鳞状细胞癌的浸润和淋巴转移，二者可能协同发挥作用。
