State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China.
J Org Chem. 2013 Feb 1;78(3):1254-9. doi: 10.1021/jo302288z. Epub 2013 Jan 10.
The organocatalytic Michael reaction of ketones with γ-monohalonitrodienes catalyzed by chiral prolinethiol ether under solvent-free conditions was developed. The described method represents a novel approach for accessing highly functionalized monohaloalkenes with α, β-stereocenters of up to >99% ee.
在无溶剂条件下，手性脯氨醇硫醚催化酮与γ-单卤代二烯的有机催化迈克尔加成反应被开发出来。该方法为获得具有高达 >99%ee 的α，β-手性中心的高官能化单卤代烯烃提供了一种新途径。
