Gude Dilip, Abbas Aslam, Mohiuddin Hina
Department of Internal Medicine, Princess Durru Shehvar Children's and General Hospital, Purani Haveli, Hyderabad, India.
Ann Card Anaesth. 2013 Jan-Mar;16(1):63-5. doi: 10.4103/0971-9784.105375.
Antagonists of vitamin K dependant clotting factors are commonly used as treatment/prophylaxis for anticoagulation. Due to their narrow therapeutic window, a wide range of complications including death may occur. International normalized ratio (INR) is monitored to measure adequacy/excess of anticoagulation. There is a plethora of risk factors that may contribute to the uncontrollably high INR values. We describe our experience of a case of deep venous thrombosis wherein the patient had an overshoot of INR during anticoagulation therapy. We review the literature and discuss management in such scenarios.
维生素K依赖性凝血因子拮抗剂通常用作抗凝治疗/预防。由于其治疗窗狭窄，可能会出现包括死亡在内的多种并发症。监测国际标准化比值（INR）以衡量抗凝是否充分/过量。有许多危险因素可能导致INR值 uncontrollably high（此处原文有误，推测可能是“uncontrollably high”，意为“不可控制地升高”）。我们描述了一例深静脉血栓形成患者在抗凝治疗期间INR过高的病例经验。我们回顾了文献并讨论了此类情况下的管理。
