将JNK-STAT3-Akt信号轴与EZH2磷酸化联系起来：一种新的致癌途径。 - Suppr

Suppr

超能文献

Linking JNK-STAT3-Akt signaling axis to EZH2 phosphorylation: a novel pathway of carcinogenesis.

作者信息

Rojanasakul Yon

机构信息

Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV, USA.

出版信息

Cell Cycle. 2013 Jan 15;12(2):202-3. doi: 10.4161/cc.23419. Epub 2012 Jan 15.

DOI:10.4161/cc.23419

PMID:23287465

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3575446/

Abstract

摘要

相似文献

Linking JNK-STAT3-Akt signaling axis to EZH2 phosphorylation: a novel pathway of carcinogenesis.将JNK-STAT3-Akt信号轴与EZH2磷酸化联系起来：一种新的致癌途径。

Cell Cycle. 2013 Jan 15;12(2):202-3. doi: 10.4161/cc.23419. Epub 2012 Jan 15.

JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic.砷诱导支气管上皮细胞中 JNK 和 STAT3 信号通路汇聚于 Akt 介导的 EZH2 磷酸化。

Cell Cycle. 2013 Jan 1;12(1):112-21. doi: 10.4161/cc.23030. Epub 2012 Dec 19.

Reactive oxygen species contribute to arsenic-induced EZH2 phosphorylation in human bronchial epithelial cells and lung cancer cells.活性氧自由基导致人类支气管上皮细胞和肺癌细胞中 EZH2 的磷酸化。

Toxicol Appl Pharmacol. 2014 May 1;276(3):165-70. doi: 10.1016/j.taap.2014.02.005. Epub 2014 Feb 25.

Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells.EZH2 的磷酸化通过 STAT3 甲基化激活 STAT3 信号通路，并促进神经胶质瘤干细胞样细胞的致瘤性。

Cancer Cell. 2013 Jun 10;23(6):839-52. doi: 10.1016/j.ccr.2013.04.008. Epub 2013 May 16.

JNK-dependent Stat3 phosphorylation contributes to Akt activation in response to arsenic exposure.JNK 依赖性 Stat3 磷酸化有助于砷暴露时 Akt 的激活。

Toxicol Sci. 2012 Oct;129(2):363-71. doi: 10.1093/toxsci/kfs199. Epub 2012 Jun 13.

Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation.致癌类金属砷通过 JNK 和 STAT3 的激活诱导 mdig 癌基因的表达。

Cancer Lett. 2014 May 1;346(2):257-63. doi: 10.1016/j.canlet.2014.01.002. Epub 2014 Jan 14.

c-Jun NH(2)-terminal kinase mediates leptin-stimulated androgen-independent prostate cancer cell proliferation via signal transducer and activator of transcription 3 and Akt.c-Jun氨基末端激酶通过信号转导和转录激活因子3及Akt介导瘦素刺激的雄激素非依赖性前列腺癌细胞增殖。

Biochim Biophys Acta. 2008 Oct;1782(10):593-604. doi: 10.1016/j.bbadis.2008.07.005. Epub 2008 Aug 5.

Methylation by EZH2 activates STAT3 in glioblastoma.EZH2 甲基化激活胶质母细胞瘤中的 STAT3。

Cancer Discov. 2013 Jul;3(7):OF21. doi: 10.1158/2159-8290.CD-RW2013-112. Epub 2013 May 23.

EZH2 promotes tumor progression via regulating VEGF-A/AKT signaling in non-small cell lung cancer.EZH2通过调节非小细胞肺癌中的VEGF-A/AKT信号通路促进肿瘤进展。

Cancer Lett. 2015 Apr 10;359(2):275-87. doi: 10.1016/j.canlet.2015.01.031. Epub 2015 Jan 26.

Protein kinase A-mediated phosphorylation regulates STAT3 activation and oncogenic EZH2 activity.蛋白激酶 A 介导的磷酸化调节 STAT3 的激活和致癌 EZH2 的活性。

Oncogene. 2018 Jun;37(26):3589-3600. doi: 10.1038/s41388-018-0218-z. Epub 2018 Mar 26.

引用本文的文献

Revisiting the Role of Autophagy in Cardiac Differentiation: A Comprehensive Review of Interplay with Other Signaling Pathways.重新审视自噬在心脏分化中的作用：与其他信号通路相互作用的综合综述。

Genes (Basel). 2023 Jun 24;14(7):1328. doi: 10.3390/genes14071328.

STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth.mTORC1 信号调控的 STAT3/miR-130b-3p/MBNL1 反馈环促进血管生成和肿瘤生长。

J Exp Clin Cancer Res. 2022 Oct 11;41(1):297. doi: 10.1186/s13046-022-02513-z.

The Pivotal Immunomodulatory and Anti-Inflammatory Effect of Histone-Lysine N-Methyltransferase in the Glioma Microenvironment: Its Biomarker and Therapy Potentials.组蛋白赖氨酸 N-甲基转移酶在胶质瘤微环境中的关键免疫调节和抗炎作用：其生物标志物和治疗潜力。

Anal Cell Pathol (Amst). 2021 Oct 27;2021:4907167. doi: 10.1155/2021/4907167. eCollection 2021.

Androgen-induced epigenetic modulations in the ovary.雄激素诱导的卵巢表观遗传调控。

J Endocrinol. 2021 Jun;249(3):R53-R64. doi: 10.1530/JOE-20-0578.

IL22 drives cutaneous melanoma cell proliferation, migration and invasion through activation of miR-181/STAT3/AKT axis.白细胞介素-22通过激活miR-181/信号转导和转录激活因子3/蛋白激酶B轴驱动皮肤黑色素瘤细胞的增殖、迁移和侵袭。

J Cancer. 2020 Feb 19;11(9):2679-2687. doi: 10.7150/jca.40974. eCollection 2020.

Epigenetic Dysregulation at the Crossroad of Women's Cancer.女性癌症交叉路口的表观遗传失调

Cancers (Basel). 2019 Aug 16;11(8):1193. doi: 10.3390/cancers11081193.

Androgens Regulate Ovarian Gene Expression Through Modulation of Ezh2 Expression and Activity.雄激素通过调节Ezh2的表达和活性来调控卵巢基因表达。

Endocrinology. 2017 Sep 1;158(9):2944-2954. doi: 10.1210/en.2017-00145.

Regulation and role of post-translational modifications of enhancer of zeste homologue 2 in cancer development.zeste同源物2增强子的翻译后修饰在癌症发展中的调控及作用

Am J Cancer Res. 2016 Dec 1;6(12):2737-2754. eCollection 2016.

MiR-148a Functions as a Tumor Suppressor by Targeting CCK-BR via Inactivating STAT3 and Akt in Human Gastric Cancer.微小RNA-148a通过靶向胆囊收缩素B受体并使信号转导和转录激活因子3及蛋白激酶B失活在人胃癌中发挥肿瘤抑制作用。

PLoS One. 2016 Aug 12;11(8):e0158961. doi: 10.1371/journal.pone.0158961. eCollection 2016.

Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation.致癌类金属砷通过 JNK 和 STAT3 的激活诱导 mdig 癌基因的表达。

Cancer Lett. 2014 May 1;346(2):257-63. doi: 10.1016/j.canlet.2014.01.002. Epub 2014 Jan 14.

本文引用的文献

Cell Cycle. 2013 Jan 1;12(1):112-21. doi: 10.4161/cc.23030. Epub 2012 Dec 19.

Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells.Akt 和 Oct4 的相互调节促进了胚胎癌细胞的自我更新和存活。

Mol Cell. 2012 Nov 30;48(4):627-40. doi: 10.1016/j.molcel.2012.08.030. Epub 2012 Oct 4.

JNK-dependent Stat3 phosphorylation contributes to Akt activation in response to arsenic exposure.JNK 依赖性 Stat3 磷酸化有助于砷暴露时 Akt 的激活。

Toxicol Sci. 2012 Oct;129(2):363-71. doi: 10.1093/toxsci/kfs199. Epub 2012 Jun 13.

SPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis.SPRY2 缺失增强了 ErbB 转运和 PI3K/AKT 信号通路，从而驱动人和小鼠前列腺癌的发生。

EMBO Mol Med. 2012 Aug;4(8):776-90. doi: 10.1002/emmm.201100944. Epub 2012 May 31.

Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways.Spry2 的失活通过激活 MAPK 和 PKM2 通路加速 AKT 驱动的肝癌发生。

J Hepatol. 2012 Sep;57(3):577-83. doi: 10.1016/j.jhep.2012.04.026. Epub 2012 May 19.

JNK-induced apoptosis, compensatory growth, and cancer stem cells.JNK 诱导的细胞凋亡、代偿性生长与癌症干细胞。

Cancer Res. 2012 Jan 15;72(2):379-86. doi: 10.1158/0008-5472.CAN-11-1982.

The role of EZH2 in tumour progression.EZH2 在肿瘤进展中的作用。

Br J Cancer. 2012 Jan 17;106(2):243-7. doi: 10.1038/bjc.2011.551. Epub 2011 Dec 20.

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation.人类肝癌细胞的增殖以及化学诱导的小鼠肝癌需要JNK1依赖的p21下调。

J Clin Invest. 2008 Dec;118(12):3943-53. doi: 10.1172/JCI37156. Epub 2008 Nov 6.

Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.Akt介导的EZH2磷酸化抑制组蛋白H3赖氨酸27的甲基化。

Science. 2005 Oct 14;310(5746):306-10. doi: 10.1126/science.1118947.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验