奥马珠单抗治疗伴有囊性纤维化的激素依赖型变应性支气管肺曲霉病（ABPA）
Omalizumab in the management of steroid dependent allergic bronchopulmonary aspergillosis (ABPA) complicating cystic fibrosis.
机构信息
Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney, Sydney, Australia.
出版信息
Paediatr Respir Rev. 2013 Mar;14(1):22-4. doi: 10.1016/j.prrv.2012.11.004. Epub 2013 Jan 1.
Allergic bronchopulmonary aspergillosis [ABPA] complicates cystic fibrosis in around 10% of teenagers. Systemic corticosteroids are the mainstay of treatment but with on-going use are associated with significant side effects prompting consideration of steroid sparing therapies. The clinical courses over ten years of two children with CF complicated by steroid dependent chronic ABPA and its successful treatment with monthly omalizumab are reported.
变应性支气管肺曲霉病[ABPA]在约 10%的青少年囊性纤维化患者中并发。全身皮质类固醇是治疗的主要方法，但长期使用会导致严重的副作用，促使考虑使用类固醇节约疗法。本文报告了两例 CF 合并类固醇依赖的慢性 ABPA 患儿的 10 年临床病程及其成功的奥马珠单抗每月治疗。
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