奥马珠单抗治疗囊性纤维化儿童的变应性支气管肺曲霉病：已发表证据的综合分析
Omalizumab therapy for allergic bronchopulmonary aspergillosis in children with cystic fibrosis: a synthesis of published evidence.
作者信息
Tanou Kalliopi, Zintzaras Elias, Kaditis Athanasios G
机构信息
Pediatric Pulmonology Unit, First Department of Pediatrics, University of Athens School of Medicine and Aghia Sophia Children's Hospital, Athens, Greece.
出版信息
Pediatr Pulmonol. 2014 May;49(5):503-7. doi: 10.1002/ppul.22937. Epub 2013 Oct 25.
Allergic bronchopulmonary aspergillosis (ABPA) complicating cystic fibrosis (CF) is treated with corticosteroids. Since elevated IgE is a cardinal abnormality, anti-IgE has been used sporadically as adjuvant treatment. In eight case reports, 13 children with CF and ABPA received anti-IgE resulting in improved FEV1 , fewer respiratory symptoms and decreased corticosteroid use.
变应性支气管肺曲霉病（ABPA）合并囊性纤维化（CF）采用皮质类固醇进行治疗。由于IgE升高是一项主要异常，抗IgE已偶尔用作辅助治疗。在8篇病例报告中，13例患有CF和ABPA的儿童接受了抗IgE治疗，结果FEV1改善、呼吸道症状减少且皮质类固醇使用量降低。
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