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Relative rates at which dominant-lethal mutations and heritable translocations are induced by alkylating chemicals in postmeiotic male germ cells of mice.烷化剂化学物质在小鼠减数分裂后雄性生殖细胞中诱导显性致死突变和可遗传易位的相对速率。
Genetics. 1979 Sep;93(1):163-71. doi: 10.1093/genetics/93.1.163.
2
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Chemical induction of presumed dominant-lethal mutations in postcopulation germ cells and zygotes of mice. II. Sensitivity of different postcopulation-precleavage stages to three alkylating chemicals.小鼠交配后生殖细胞和受精卵中假定显性致死突变的化学诱导。II. 不同交配后卵裂前阶段对三种烷化剂的敏感性
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Difference in the ratio of dominant-lethal mutations to heritable translocations produced in mouse spermatids and fully mature sperm after treatment with triethylenemelamine (TEM).用三亚乙基三聚氰胺（TEM）处理后，小鼠精子细胞和完全成熟精子中产生的显性致死突变与可遗传易位的比例差异。
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Effects of dose on the induction of dominant-lethal mutations with triethylenemelamine in male mice.剂量对雄性小鼠中三乙烯三聚氰胺诱导显性致死突变的影响。
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Studies on DNA repair in early spermatid stages of male mice after in vivo treatment with methyl-, ethyl-, propyl-, and isopropyl methanesulfonate.用甲基、乙基、丙基和异丙基甲磺酸对雄性小鼠进行体内处理后，对早期精子细胞阶段DNA修复的研究。
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Lack of association between induction of dominant-lethal mutations and induction of heritable translocations with benzo[a]pyrene in postmeiotic germ cells of male mice.
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Effects of dose on the induction of dominant-lethal mutations and heritable translocations with ethyl methanesulfonate in male mice.剂量对甲磺酸乙酯诱导雄性小鼠显性致死突变和可遗传易位的影响。
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Chemical induction of presumed dominant-lethal mutations in postcopulation germ cells of mice. I. Relative sensitivity between pre- and postcopulation germ cells to isopropyl methanesulfonate.
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Reactive oxygen species in spermatozoa: methods for monitoring and significance for the origins of genetic disease and infertility.精子中的活性氧物种：监测方法及其对遗传疾病起源和不孕症的意义
Reprod Biol Endocrinol. 2005 Nov 29;3:67. doi: 10.1186/1477-7827-3-67.
2
Difference in the ratio of dominant-lethal mutations to heritable translocations produced in mouse spermatids and fully mature sperm after treatment with triethylenemelamine (TEM).用三亚乙基三聚氰胺（TEM）处理后，小鼠精子细胞和完全成熟精子中产生的显性致死突变与可遗传易位的比例差异。
Genetics. 1982 Apr;100(4):633-40. doi: 10.1093/genetics/100.4.633.

本文引用的文献

1
Effects of dose on the induction of dominant-lethal mutations and heritable translocations with ethyl methanesulfonate in male mice.剂量对甲磺酸乙酯诱导雄性小鼠显性致死突变和可遗传易位的影响。
Genetics. 1974 Aug;77(4):741-52. doi: 10.1093/genetics/77.4.741.
2
Premature chromosome condensation, structural chromosome aberrations, and micronuclei in early mouse embryos after treatment of paternal postmeiotic germ cells with triethylenemelamine: possible mechanisms for chemically induced dominant-lethal mutatiions.
Mutat Res. 1975 Dec;33(2-3):251-60. doi: 10.1016/0027-5107(75)90201-8.
3
Timing of sperm penetration, pronuclear formation, pronuclear DNA synthesis, and first cleavage in naturally ovulated mouse eggs.
J Exp Zool. 1977 Nov;202(2):245-52. doi: 10.1002/jez.1402020214.
4
Expression of TEM-induced damage to postmeiotic stages of spermatogenesis of the mouse during early embryogenesis. II. Cytological investigations.胚胎发育早期TEM诱导的对小鼠精子发生减数分裂后阶段的损伤表达。II. 细胞学研究。
Mutat Res. 1978 Oct;52(1):107-15. doi: 10.1016/0027-5107(78)90099-4.
5
The production of chromosome aberrations in various mammalian cells by triethylenemelamine.三亚乙基三聚氰胺对各种哺乳动物细胞染色体畸变的诱导作用
Genetics. 1978 Feb;88(2):317-26. doi: 10.1093/genetics/88.2.317.

烷化剂化学物质在小鼠减数分裂后雄性生殖细胞中诱导显性致死突变和可遗传易位的相对速率。

Relative rates at which dominant-lethal mutations and heritable translocations are induced by alkylating chemicals in postmeiotic male germ cells of mice.

作者信息

Generoso W M, Huff S W, Cain K T

出版信息

Genetics. 1979 Sep;93(1):163-71. doi: 10.1093/genetics/93.1.163.

DOI:10.1093/genetics/93.1.163
PMID:232878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1217823/
Abstract

There is a close relationship between the rates at which dominant lethal mutations and heritable translocations are induced by ethyl methanesulfonate (EMS) or triethylenemelamine (TEM) in male postmeiotic germ cells. This relationship does not hold for isopropyl methanesulfonate (IMS), which induced only negligible frequencies of heritable translocations at doses that induced high levels of dominant lethal mutations. Nor does IMS behave like EMS and TEM in the degree to which eggs of different stocks of females repair premutational lesions that are carried in the sperm-large differences between stocks for IMS treatment and small differences for EMS or TEM treatment. These dissimilarities between IMS and the other two alkylating chemicals are postulated to be attributable to differences in the types of lesions present at the time of repair activity and to whether or not chromosomal aberrations are already fixed prior to postfertilization pronuclear DNA synthesis.

摘要

甲磺酸乙酯（EMS）或三亚乙基蜜胺（TEM）在雄性减数分裂后生殖细胞中诱导显性致死突变和可遗传易位的速率之间存在密切关系。这种关系不适用于甲磺酸异丙酯（IMS），在诱导高水平显性致死突变的剂量下，IMS仅诱导出可忽略不计频率的可遗传易位。在不同品系雌性的卵子修复精子中携带的前突变损伤的程度方面，IMS的表现也与EMS和TEM不同——对于IMS处理，品系间差异很大，而对于EMS或TEM处理，品系间差异很小。推测IMS与其他两种烷化剂之间的这些差异可归因于修复活性时存在的损伤类型的差异，以及染色体畸变在受精后原核DNA合成之前是否已经固定。